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Database: UniProt/TrEMBL
Entry: B8NKQ2_ASPFN
LinkDB: B8NKQ2_ASPFN
Original site: B8NKQ2_ASPFN 
ID   B8NKQ2_ASPFN            Unreviewed;       980 AA.
AC   B8NKQ2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   05-JUL-2017, entry version 56.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=AFLA_093060 {ECO:0000313|EMBL:EED49225.1};
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM
OS   12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=332952 {ECO:0000313|EMBL:EED49225.1, ECO:0000313|Proteomes:UP000001875};
RN   [1] {ECO:0000313|EMBL:EED49225.1, ECO:0000313|Proteomes:UP000001875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
RC   {ECO:0000313|Proteomes:UP000001875};
RX   PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; EQ963480; EED49225.1; -; Genomic_DNA.
DR   RefSeq; XP_002381126.1; XM_002381085.1.
DR   STRING; 5059.CADAFLAP00008991; -.
DR   EnsemblFungi; EED49225; EED49225; AFLA_093060.
DR   GeneID; 7913671; -.
DR   KEGG; afv:AFLA_093060; -.
DR   EuPathDB; FungiDB:AFLA_093060; -.
DR   HOGENOM; HOG000176213; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001875};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EED49225.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001875}.
FT   DOMAIN      398    523       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      692    777       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      864    976       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      639    666       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   980 AA;  111738 MW;  835C95FDA9E9285F CRC64;
     MDSDDDYNGP ADTNPRLEDE ESDLDENEIK KKPAGPARKK VGPHGLSSVN LTPLEKRRDI
     IDRFISRWRK EVGDDIYPAF RLILPDKDRD RAMYGMKEKA IGKLLIRIMK IDKNSEDALN
     LLNWKLPGQT TTSSMAGDFA GRCFGVLSKR PMRTEVGDMT IEEVNEKLDH LSAASKENQQ
     LPILTEFYRR MNPEELMWLI RIILRQMKVG ATERTFFDVF HPDAENLYSI SSSLRRVCWE
     LHDPNIRLEA EDRGITLMQC FQPQLAQFQM HSLDRMISRM RLTEDDPVFW IEEKLDGERM
     QLHMDSNDSV PGGRTFRFWS RKAKDYTYLY GNGIQDENGA LTRYLNDAFA DGVESLILDG
     EMITWDTEQD AIAPFGTLKT AALSEQRNPY SSTTRPLFRI FDILYLNGRD LTRYTLRDRR
     NALQKSIKPV YRRFEIHPYE EATGKTEIEE ALRRVVEEAS EGLVLKNPRS PYRLNERHDD
     WMKVKPEYMT EFGESLDVVV IGGYYGSGHR GGGLSSFLCG LRVDDAHSSQ GMVASKCYSF
     CKVGGGFTAA DYANIRHHTD GKWHEWKSRK PPTTYIELAG GDAQYERPDM WIKPEDSVVL
     CVKAASVAVS DQFRIGLTLR FPRFKKLRMD KDWKSALSVQ EFLDLKANAE RERKEKEFNV
     DNSRKKRAKR DNKKPLAIAG YSAEAEAQYT GPSGNIFEGL NFYITTDSNT PVKKSKAELE
     QLVKANGGKF FQTSNAAPST ICIADRRTVK AASLQKSGNV NIIRPSWILD CIRQSEIDAG
     LPDSLLPLEP RHVFFATQDK KEEIAASVDR FNDSYARNTT NDELKEILKQ MSKDHHFHAS
     QNPKIVRKLN ERIQEKVNAG WEMPSGWLFK GLTILFPQND KVDDAEVDET SQTHQQYRLN
     LARNTVRFAG ANVVDSKSSS VTHIVVAPGS SSSDVSSIRK SHSAKPGKKV PHLVTAEWIE
     ECWKQRTLLG EEGFQPSRGT
//
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