ID B8ZLT6_STRPJ Unreviewed; 252 AA.
AC B8ZLT6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 01-MAY-2013, entry version 30.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
GN Name=tpi; Synonyms=tpiA; OrderedLocusNames=SPN23F15910;
OS Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=561276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700669 / Spain 23F-1;
RX PubMed=19114491; DOI=10.1128/JB.01343-08;
RA Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K.,
RA Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J.,
RA Bentley S.D., Mitchell T.J.;
RT "Role of conjugative elements in the evolution of the multidrug-
RT resistant pandemic clone Streptococcus pneumoniae Spain23F ST81.";
RL J. Bacteriol. 191:1480-1489(2009).
CC -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC phosphate.
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR EMBL; FM211187; CAR69369.1; -; Genomic_DNA.
DR RefSeq; YP_002511488.1; NC_011900.1.
DR ProteinModelPortal; B8ZLT6; -.
DR SMR; B8ZLT6; 3-251.
DR STRING; 561276.SPN23F_15910; -.
DR GeneID; 7328798; -.
DR KEGG; sne:SPN23F_15910; -.
DR PATRIC; 19674540; VBIStrPne132160_1672.
DR eggNOG; COG0149; -.
DR KO; K01803; -.
DR OMA; ANTVIAY; -.
DR ProtClustDB; PRK00042; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00147_B; TIM_B; 1; -.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; Triophos_ismrse; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW Pentose shunt.
FT ACT_SITE 96 96 Electrophile (By similarity).
FT ACT_SITE 168 168 Proton acceptor (By similarity).
FT BINDING 10 10 Substrate (By similarity).
FT BINDING 12 12 Substrate (By similarity).
SQ SEQUENCE 252 AA; 26550 MW; 8B6493EF645DE62F CRC64;
MSRKPFIAGN WKMNKNPEEA KAFVEAVASK LPSSDLVEAG IAAPALDLTT VLAVAKGSNL
KVAAQNCYFE NAGAFTGETS PQVLKEIGTD YVVIGHSERR DYFHETDEDI NKKAKAIFAN
GMLPIICCGE SLETYEAGKA AEFVGAQVSA ALAGLTAEQV AASVIAYEPI WAIGTGKSAS
QDDAQKMCKV VRDVVAADFG QEVADKVRVQ YGGSVKPENV ASYMACPDVD GALVGGASLE
AESFLALLDF VK
//
