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Database: UniProt/TrEMBL
Entry: B9HKQ7_POPTR
LinkDB: B9HKQ7_POPTR
Original site: B9HKQ7_POPTR 
ID   B9HKQ7_POPTR            Unreviewed;       416 AA.
AC   B9HKQ7;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   05-OCT-2016, entry version 48.
DE   RecName: Full=Diphosphomevalonate decarboxylase {ECO:0000256|RuleBase:RU363086};
DE            EC=4.1.1.33 {ECO:0000256|RuleBase:RU363086};
DE   AltName: Full=Mevalonate pyrophosphate decarboxylase {ECO:0000256|RuleBase:RU363086};
GN   ORFNames=POPTR_0008s02200g {ECO:0000313|EMBL:EEE88382.1};
OS   Populus trichocarpa (Western balsam poplar) (Populus balsamifera
OS   subsp. trichocarpa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae;
OC   Populus.
OX   NCBI_TaxID=3694 {ECO:0000313|EMBL:EEE88382.1, ECO:0000313|Proteomes:UP000006729};
RN   [1] {ECO:0000313|EMBL:EEE88382.1, ECO:0000313|Proteomes:UP000006729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX   PubMed=16973872; DOI=10.1126/science.1128691;
RA   Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA   Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA   Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D.,
RA   Boerjan W., Brun A., Brunner A., Busov V., Campbell M., Carlson J.,
RA   Chalot M., Chapman J., Chen G.-L., Cooper D., Coutinho P.M.,
RA   Couturier J., Covert S., Cronk Q., Cunningham R., Davis J.,
RA   Degroeve S., Dejardin A., dePamphilis C.W., Detter J., Dirks B.,
RA   Dubchak I., Duplessis S., Ehlting J., Ellis B., Gendler K.,
RA   Goodstein D., Gribskov M., Grimwood J., Groover A., Gunter L.,
RA   Hamberger B., Heinze B., Helariutta Y., Henrissat B., Holligan D.,
RA   Holt R., Huang W., Islam-Faridi N., Jones S., Jones-Rhoades M.,
RA   Jorgensen R., Joshi C., Kangasjaervi J., Karlsson J., Kelleher C.,
RA   Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA   Leebens-Mack J., Leple J.-C., Locascio P., Lou Y., Lucas S.,
RA   Martin F., Montanini B., Napoli C., Nelson D.R., Nelson C.,
RA   Nieminen K., Nilsson O., Pereda V., Peter G., Philippe R., Pilate G.,
RA   Poliakov A., Razumovskaya J., Richardson P., Rinaldi C., Ritland K.,
RA   Rouze P., Ryaboy D., Schmutz J., Schrader J., Segerman B., Shin H.,
RA   Siddiqui A., Sterky F., Terry A., Tsai C.-J., Uberbacher E.,
RA   Unneberg P., Vahala J., Wall K., Wessler S., Yang G., Yin T.,
RA   Douglas C., Marra M., Sandberg G., Van de Peer Y., Rokhsar D.S.;
RT   "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL   Science 313:1596-1604(2006).
CC   -!- FUNCTION: Performs the first committed step in the biosynthesis of
CC       isoprene-containing compounds such as sterols and terpenoids.
CC       {ECO:0000256|RuleBase:RU363086}.
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-5-diphosphomevalonate = ADP +
CC       phosphate + isopentenyl diphosphate + CO(2).
CC       {ECO:0000256|RuleBase:RU363086}.
CC   -!- SIMILARITY: Belongs to the diphosphomevalonate decarboxylase
CC       family. {ECO:0000256|RuleBase:RU363086}.
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DR   EMBL; CM000344; EEE88382.1; -; Genomic_DNA.
DR   RefSeq; XP_002311015.1; XM_002310979.2.
DR   ProteinModelPortal; B9HKQ7; -.
DR   STRING; 3694.POPTR_0008s02200.1; -.
DR   EnsemblPlants; POPTR_0008s02200.1; POPTR_0008s02200.1; POPTR_0008s02200.
DR   GeneID; 7490899; -.
DR   Gramene; POPTR_0008s02200.1; POPTR_0008s02200.1; POPTR_0008s02200.
DR   KEGG; pop:POPTR_0008s02200g; -.
DR   eggNOG; KOG2833; Eukaryota.
DR   eggNOG; COG3407; LUCA.
DR   HOGENOM; HOG000081923; -.
DR   InParanoid; B9HKQ7; -.
DR   KO; K01597; -.
DR   OMA; MNDVSHS; -.
DR   OrthoDB; EOG09360AEL; -.
DR   Proteomes; UP000006729; Linkage group LGVIII.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004163; F:diphosphomevalonate decarboxylase activity; IBA:GO_Central.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR005935; Mev_decarb.
DR   InterPro; IPR029765; Mev_diP_decarb.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10977; PTHR10977; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF015950; Mev_P_decrbx; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR01240; mevDPdecarb; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU363086};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006729};
KW   Lipid biosynthesis {ECO:0000256|RuleBase:RU363086};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU363086};
KW   Lyase {ECO:0000256|RuleBase:RU363086};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363086};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW   Steroid biosynthesis {ECO:0000256|RuleBase:RU363086};
KW   Steroid metabolism {ECO:0000256|RuleBase:RU363086};
KW   Sterol biosynthesis {ECO:0000256|RuleBase:RU363086};
KW   Sterol metabolism {ECO:0000256|RuleBase:RU363086}.
FT   DOMAIN      113    171       GHMP_kinases_N. {ECO:0000259|Pfam:
FT                                PF00288}.
SQ   SEQUENCE   416 AA;  45655 MW;  C1C279743D5F47E9 CRC64;
     MAEKTWVRMV TAQTPTNIAV IKYWGKRDET LILPVNDSIS VTLDPAHLCT TTTVAVSPSF
     DQDRMWLNGK EISLSGGRYQ NCLREIRARA CAVEDKEKGI KIAKKDWEKL HLHVASYNNF
     PTAAGLASSA AGFACLVFAL AKLMNAKEDN SELSAIARQG SGSACRSLFG GFVKWIMGKA
     EDGSDSLAVQ LVDEKHWDEL VIIIAVVSSR QKETSSTTGM RDSVETSLLL QHRAKEVVPK
     RIKQMEEAIK NRDFGSFAQL SCADSNQFHA VCLDTCPPIF YMNDTSHRII SCVEKWNCSE
     GTPQVAYTFD AGPNAVLIAH NRKAATQLMQ KLLFCFPPSS DADLNSYVIG DKSILKDAGI
     EDIKDVEALP PPPEIKDAQR CKGDVSYFIC TKPGRGPALL SDESQALLHP ETGLPK
//
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