ID B9KI66_ANAMF Unreviewed; 529 AA.
AC B9KI66;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Penicillin-binding protein (PbpA2) {ECO:0000313|EMBL:ACM49178.1};
GN Name=pbpA2 {ECO:0000313|EMBL:ACM49178.1};
GN OrderedLocusNames=AMF_307 {ECO:0000313|EMBL:ACM49178.1};
OS Anaplasma marginale (strain Florida).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Anaplasma.
OX NCBI_TaxID=320483 {ECO:0000313|EMBL:ACM49178.1, ECO:0000313|Proteomes:UP000007307};
RN [1] {ECO:0000313|EMBL:ACM49178.1, ECO:0000313|Proteomes:UP000007307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Florida {ECO:0000313|EMBL:ACM49178.1,
RC ECO:0000313|Proteomes:UP000007307};
RX PubMed=19134224; DOI=10.1186/1471-2164-10-16;
RA Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E.,
RA Palmer G.H., Knowles D.P. Jr., Brayton K.A.;
RT "Conservation in the face of diversity: multistrain analysis of an
RT intracellular bacterium.";
RL BMC Genomics 10:16-16(2009).
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DR EMBL; CP001079; ACM49178.1; -; Genomic_DNA.
DR RefSeq; WP_010267398.1; NC_012026.1.
DR AlphaFoldDB; B9KI66; -.
DR STRING; 320483.AMF_307; -.
DR GeneID; 7398416; -.
DR KEGG; amf:AMF_307; -.
DR PATRIC; fig|320483.3.peg.360; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_2_5; -.
DR Proteomes; UP000007307; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007307};
KW Transferase {ECO:0000256|ARBA:ARBA00022676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..173
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 224..515
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 529 AA; 58280 MW; E818D6813E578162 CRC64;
MDHVGQIFDR CELRNETLNK SKKRLLCATI PFVVFFIIIT FRLITLTAVP HEEIKPAVSK
NAQPKGRFTI LDRNGEILAT DIATVSLSAD TTVMSNPELV IEKVSAILHD DSERIRRLLS
PKKKFIWIKR DITSTEAAEI KEARLKGLHL TQEVKRVYPH NNLLSHILGY VDPDGRGISG
IERYADIFGV QGDVKLSVDV RVQNVVREEI LRQMEKYNAA AGIGIVMDVR NGEILAAVSL
PDFDLNNRSK AENYQKFNRV TLGVYEMGSV FKLFTVASAI DSGKVSVEDT YDVSQPFIIG
RYKVNDMYKS RSPVLSVREI FAQSSNVGMA KIAMDLGKDI QLEYFERMDL LSDLGLEIPE
VGFPIFPREW SNSTVATASY GYGVAVTPVH VVQAAAGLVN DGIMHDATLI FGKGTEGRRV
VSSETSRKVK QLLRFAVERG TGKRANVKGY LVGGKTGSAE KVIDGRYRKD ANLASFLGIF
PISEPKYAIM VMIDEPKGSK VTGGAVSAPV VGRIISRMAP ILSIAPVAG
//
