ID   B9L8N3_NAUPA            Unreviewed;       579 AA.
AC   B9L8N3;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   01-MAY-2013, entry version 25.
DE   SubName: Full=Quinone-reactive Ni/Fe-hydrogenase large chain;
DE            EC=1.12.5.1;
GN   OrderedLocusNames=NAMH_0575;
OS   Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Nautiliales;
OC   Nautiliaceae; Nautilia.
OX   NCBI_TaxID=598659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1463 / DSM 18972 / AmH;
RX   PubMed=19197347; DOI=10.1371/journal.pgen.1000362;
RA   Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y.,
RA   Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.;
RT   "Adaptations to submarine hydrothermal environments exemplified by the
RT   genome of Nautilia profundicola.";
RL   PLoS Genet. 5:E1000362-E1000362(2009).
CC   -!- SIMILARITY: Belongs to the [NiFe]/[NiFeSe] hydrogenase large
CC       subunit family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001279; ACM92168.1; -; Genomic_DNA.
DR   RefSeq; YP_002606991.1; NC_012115.1.
DR   STRING; 598659.NAMH_0575; -.
DR   EnsemblBacteria; ACM92168; ACM92168; NAMH_0575.
DR   GeneID; 7504027; -.
DR   KEGG; nam:NAMH_0575; -.
DR   PATRIC; 22675869; VBINauPro131435_0552.
DR   eggNOG; COG0374; -.
DR   HOGENOM; HOG000278799; -.
DR   KO; K05922; -.
DR   OMA; VHFYHLS; -.
DR   ProtClustDB; CLSK872401; -.
DR   BioCyc; NPRO598659:GH7N-106-MONOMER; -.
DR   GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR   GO; GO:0047067; F:hydrogen:quinone oxidoreductase activity; IEA:EC.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   InterPro; IPR001501; Ni-dep_hyd_lsu.
DR   InterPro; IPR018194; Ni-dep_hyd_lsu_Ni_BS.
DR   Pfam; PF00374; NiFeSe_Hases; 1.
DR   PROSITE; PS00507; NI_HGENASE_L_1; 1.
DR   PROSITE; PS00508; NI_HGENASE_L_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; Nickel; Oxidoreductase.
SQ   SEQUENCE   579 AA;  64829 MW;  E1DA53F66F917F34 CRC64;
     MAKRVVIDPI TRIEGHLRVE VVVDENNKIT NAFSSATLWR GIEVILKGRD PRDAGFMTQR
     ICGVCTYSHY KAGITAVEDA LGIKPPLNAL LTRTLMDFAL FFHDHIVHFY QLHALDWVDI
     ISALKADPKK ASEEAFKYVP KGYNPIATGE DELREVQKRV SKFAEKGDLG PFKNGYWGHK
     TMKFTPEQNL IALSHYLKTL EMQRIAAQMM AIFGGKNPHP QSLTVGGVTC VMDLQDPARL
     GEYLTKFQEL ADYVNRAYYA DIVMAASAYG TEPSVVQKTN LGNFLTYKTM QTGPNSWLFD
     ACGYIKNHDL TKFYEIDESK ITEEATHSWY KNLDNPTHPY DETTEPEYTG YVEGESVDGQ
     GNIVKTKVVN EKGKYSWIKS PRYNEEPMEV GPLACMVVNY AAGNKKVQKV VNEFLAQTGL
     PAEALFTVLG RTAARMLQTK TIADYGLEAF NNLVENLKKD QTTVAPYVID ETKEYKGRFI
     GDVPRGMLSH WCRIKNGKIE NWQAVVPSTW NAGPEDGRGK KGAYEANLIG MTLADPAKPL
     EVIRSIHSYD PCIACAVHVM DVKGKKLGEF KVDPLYGAC
//