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Database: UniProt/TrEMBL
Entry: C0MAP0_STRE4
LinkDB: C0MAP0_STRE4
Original site: C0MAP0_STRE4 
ID   C0MAP0_STRE4            Unreviewed;      1546 AA.
AC   C0MAP0;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 63.
DE   SubName: Full=Glycosyl hydrolase family protein {ECO:0000313|EMBL:CAW94606.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=SEQ_1612 {ECO:0000313|EMBL:CAW94606.1};
OS   Streptococcus equi subsp. equi (strain 4047).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553482 {ECO:0000313|EMBL:CAW94606.1, ECO:0000313|Proteomes:UP000001365};
RN   [1] {ECO:0000313|EMBL:CAW94606.1, ECO:0000313|Proteomes:UP000001365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4047 {ECO:0000313|EMBL:CAW94606.1,
RC   ECO:0000313|Proteomes:UP000001365};
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K.,
RA   Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K.,
RA   Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K.,
RA   Aanensen D.M., Spratt B.G., Jolley K.A., Maiden M.C.J., Kehoe M.,
RA   Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J.,
RA   Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00569680}.
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DR   EMBL; FM204883; CAW94606.1; -; Genomic_DNA.
DR   RefSeq; WP_012679871.1; NC_012471.1.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH16; Glycoside Hydrolase Family 16.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   EnsemblBacteria; CAW94606; CAW94606; SEQ_1612.
DR   KEGG; seu:SEQ_1612; -.
DR   HOGENOM; HOG000071801; -.
DR   KO; K01186; -.
DR   OMA; ENDYELI; -.
DR   OrthoDB; POG091H03M1; -.
DR   BioCyc; SEQU553482:GJOY-1595-MONOMER; -.
DR   Proteomes; UP000001365; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR003305; CenC_carb-bd.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR000757; GH16.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR011040; Sialidases.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02018; CBM_4_9; 1.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF50939; SSF50939; 2.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS51762; GH16_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001365};
KW   Hydrolase {ECO:0000313|EMBL:CAW94606.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Secreted {ECO:0000256|SAAS:SAAS00085696};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     21     42       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      239    550       GH16 (glycosyl hydrolase family 16).
FT                                {ECO:0000259|PROSITE:PS51762}.
SQ   SEQUENCE   1546 AA;  169799 MW;  794C51295FCB4E0D CRC64;
     MLFNPIGKEQ IRKYAIKKLS VGVASVCVGI GLAAGLPVAV YADDVSEVSL QQPTKAAVTE
     ISHEQEPQAT DTDSEALVVS EETTVDEAVV ANAVTSNAAD QTADEEKSNA PIELNKVANG
     GFDNDYVSNK NQWQYREGGH SVLTTENGNS YAEVTSGTLD EHILQKVSTT VGKTYTLEAD
     VKVEADTPHN GLYLTAKESN HNLQGPVIKE VSLTDTDGTW SHIKLSFTAT TSETFVGLVK
     WLEASSPEAL AASASIDNVS VVEENDYELI WQDEFSGDRL NQENWGYELG SIRGNEQQHY
     TDSTENVYLD NGNLVLNVTE RYGEDRYANP RGGTSARQVI YDSGSVRTVG KQEFLYGRIE
     ARAKLPKGKG AFPAFWTLGA DFTLDGDIAS TQGYGWPSTG ELDIMELIGA PNGEHEGELA
     EGDQSNKTVY GTPHFYYIKG DADKDGSYSP TALGGNLTLS DDFYDDYHIF GINWYPDKIE
     WYVDGIVYNT MYLTGDDRLE AAAAAFNKPQ YLQFNLATGG NWSKNAGYYL ASDETAFVID
     YVRYYQDAEQ KAASEAYYAS QPVLKGVKDL TMLEGTSPDL AQAVTTDQEG YVVDFSVENE
     YLFTNKGGNT NAALQAAGRD DLSALSELAP GIYNIYYSAV PYNADLGSTV TPTAKIAREV
     AILTVLPKEG LIGKKGEPLS TVALPANWQW VTPEEILGSA EHYQIKYTTE GGRAVYTSIE
     ASYISDQPIS DQASILVDLG NAILDATAEK AAVTDDEALG KLDDVMNLTQ GTVTIRYRLD
     TADTTVRSSS PLALLSISNQ ASANEYASFF IEPKNNKIGL EFKGAEVPIV KVGSGFNLLT
     NSDWQTISYV FTGSRLKIYL NGDLYGEADF AGFMKQLPWK ASADTLTIGG LKRTYDGESV
     LHWGLKGLVD QVLIDTDVYD LTDIAKAHQP TLRPVTGEKT NVWDKYDEGV FEYRIPSVVK
     TPSGTLIAAA DARKKHYNDW GDVATVVRIS HDDGKTWSNN ITVLDMPTQP YFTTQYSLAD
     WNTNMTQSAF SIDSTLLTDA SGKLYLLVDV FPESQGAVAS KAGSGYELIN GQYYLNLYDF
     DNNKYTVREG GIVYDQSGHQ TDMYVDEGNF ETAFSTRGNL YQTEAGEDIL LGNIYLRSGR
     TKQGITREGS QTAPLFTYMT SFLWLLTSED EGQTWSTPLD ITPQIKEDWM GFLGTGAAAG
     IEIDAVNAEG EQVKRLVFPI YYTNQQNATS ASLGRQSSAN IFSDDGGQTW QRGESPNDGR
     IYGHNQQTTS KDFDTSVTEL TENQIIQLNN GHLLQFMRNT GKTIVIARST DYGMTWDDNP
     TITDLPEPYV NLSAIHMMVD GKEYVVLSNP LGEPSGEQLT IRNQRMKGIL RVGEVLEDDS
     IHWVASTIFE PKRFAYSSLV QLDDERVGLL YEYSGQITYS TFNIKQMISD QFREDKAEIE
     EVTITSAAPK QNGKVSITIQ MTFNQPMFIL GDRQLAVTVN GVDKLASYVS GDGTDTAIFE
     LSLESMPEGP ITVLPQFDHT IVETKYGIRL TDDKAYTVSY PAAVTA
//
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