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Database: UniProt/TrEMBL
Entry: C0MCG2_STRS7
LinkDB: C0MCG2_STRS7
Original site: C0MCG2_STRS7 
ID   C0MCG2_STRS7            Unreviewed;      1546 AA.
AC   C0MCG2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   25-OCT-2017, entry version 71.
DE   SubName: Full=Glycosyl hydrolase family protein {ECO:0000313|EMBL:CAW98510.1};
GN   OrderedLocusNames=SZO_05310 {ECO:0000313|EMBL:CAW98510.1};
OS   Streptococcus equi subsp. zooepidemicus (strain H70).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553483 {ECO:0000313|Proteomes:UP000001368};
RN   [1] {ECO:0000313|EMBL:CAW98510.1, ECO:0000313|Proteomes:UP000001368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H70 {ECO:0000313|EMBL:CAW98510.1,
RC   ECO:0000313|Proteomes:UP000001368};
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K.,
RA   Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K.,
RA   Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K.,
RA   Aanensen D.M., Spratt B.G., Jolley K.A., Maiden M.C.J., Kehoe M.,
RA   Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J.,
RA   Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00569680}.
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DR   EMBL; FM204884; CAW98510.1; -; Genomic_DNA.
DR   RefSeq; WP_012677597.1; NC_012470.1.
DR   STRING; 40041.SZO_05310; -.
DR   EnsemblBacteria; CAW98510; CAW98510; SZO_05310.
DR   GeneID; 7695084; -.
DR   KEGG; seq:SZO_05310; -.
DR   PATRIC; fig|40041.11.peg.562; -.
DR   HOGENOM; HOG000071801; -.
DR   KO; K01186; -.
DR   OMA; ENDYELI; -.
DR   OrthoDB; POG091H03M1; -.
DR   Proteomes; UP000001368; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR000757; GH16.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF50939; SSF50939; 2.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS51762; GH16_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001368};
KW   Hydrolase {ECO:0000313|EMBL:CAW98510.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001368};
KW   Secreted {ECO:0000256|SAAS:SAAS00085696};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     21     42       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      260    550       GH16. {ECO:0000259|PROSITE:PS51762}.
SQ   SEQUENCE   1546 AA;  169787 MW;  EC1A64DB75AB7E72 CRC64;
     MLFNPIGKEQ IRKYAIKKLS VGVASVCVGI GLAAGLPVVV YADDVSEVSL QQPTKAAVTE
     ISHEQEPQAT DTDSEALVVS EETTVDEAVV ANAVTSNAAD QTADEEKSNA PVELNKVANG
     GFDNDYVSNK NQWQYREGGH SVLTTENNNS YAEVTSGTLD EHILQKVSTT VGKTYTLEAD
     VKVEADTPHN GLYLTAKESN HNLQGPVIKE VSLTDTDGTW SHIKLSFTAT TSETFVGLVK
     RLEASSPETL AASASIDNVS VVEENDYELI WQDEFSGDQL NQENWGYELG SIRGNEQQHY
     TDSTENIYLE NGNLVLNVTE RKGEDRYANP RGGTSARQVI YDSGSVRTVG KQEFLYGRIE
     ARAKLPKGKG AFPAFWTLGA DFTLDGDIAS TQGYGWPSTG ELDIMELIGA PNGEHEGELA
     EGDQSNKTVY GTPHFYYVKG DADKDGSYSP TALGGNLTLS DDFYDDYHIF GINWYPDKIE
     WYVDGIVYNT MYLTGDERLE AAAAAFNKPQ YLQFNLATGG NWSKNAGYYL ASDETAFVID
     YVRYYQDAEQ KAASEAYYAS QPDLKGVKDL TMLEGTSPDL AQAVTTDQEG YVVDFSVENE
     YLFTNKGGNT NAALQAAGRD DLSALSELAP GIYNIYYSAV PYNADLGSTV TPTAKIAREV
     AILTVLPKEG LIGKKGEPLS TVALPANWQW VTPEEILGSA EHYQIKYTTE GGRAIYTSIE
     ASYISDQPIS DQASILVDLG NAILDATAEK AAVTDDEALS KLDDVMSLNQ GTVTIRYRLD
     TADTTVRSSS PLALLSISNQ ASANEYASFF IEPKNNKIGL EFKGAEVPIV KVGSGFNLLT
     NSDWQTISYV FTGSRLKIYL NGDLYGEADF AGFMKQLPWK ASADTLTIGG LKRTYDGESV
     LHWGLKGLVD QVLIDTDVYD LTDIAKAHQS TLRPVTGEKT NVWDKYDEGV FEYRIPSVVK
     TPSGTLIAAA DARKKHYNDW GDVATVVRIS HDDGKTWSNN ITVLDMPTQP YFTTQYSLAD
     WNTNMTQSAF SIDSTLLTDA SGKLYLLVDV FPESQGAVAS KAGSGYELIN GQYYLNLYDF
     DNNKYTVREG GIVYDQNGHQ TDMYVDEGNF ETAFSTRGNL YQTEAGEDIL LGNIYLRSGR
     TKQGITREGS QTAPLFTYMT SFLWLLTSED EGQTWSTPLD ITPQIKEDWM GFLGTGAAAG
     IEIDAVNAEG EQVKRLVFPI YYTNQQNATS ASLGRQSSAN IFSDDGGQTW QRGESPNDGR
     IYGHNQQTTS KDFDTSVTEL TENQIIQLNN GHLLQFMRNT GKTIVIARST DYGATWEDNP
     TVTDLPEPYV NLSAIHMMVD GKEYVVLSNP LGEPSGEQLT IRNQRMKGIL RVGEVLEDDS
     INWVASTIFE PKRFAYSSLV QLDDERVGLL YEYSGQITYS TFNIKQMISD QFREDKAEIE
     EVTITSAAPK QNGKASITIQ MTFNQPMFIL GDRQLAVTVN GVDKLASYVS GDGTDTAIFE
     LSLESMPEGP ITVLPQFDHT IVETKYGIRL TDDKAYTVSY PAAVTA
//
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