ID C0RJV3_BRUMB Unreviewed; 620 AA.
AC C0RJV3;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Heme transporter BhuA {ECO:0000256|ARBA:ARBA00021261};
GN OrderedLocusNames=BMEA_A1394 {ECO:0000313|EMBL:ACO01111.1};
OS Brucella melitensis biotype 2 (strain ATCC 23457).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=546272 {ECO:0000313|EMBL:ACO01111.1, ECO:0000313|Proteomes:UP000001748};
RN [1] {ECO:0000313|Proteomes:UP000001748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23457 {ECO:0000313|Proteomes:UP000001748};
RA Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J.,
RA Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E.,
RA Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C., Tapia R.,
RA Han C., Detter J.C., Bruce D., Brettin T.S.;
RT "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004571}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000256|RuleBase:RU003357}.
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DR EMBL; CP001488; ACO01111.1; -; Genomic_DNA.
DR RefSeq; WP_004685730.1; NC_012441.1.
DR AlphaFoldDB; C0RJV3; -.
DR KEGG; bmi:BMEA_A1394; -.
DR HOGENOM; CLU_008287_18_5_5; -.
DR Proteomes; UP000001748; Chromosome I.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR CDD; cd01347; ligand_gated_channel; 1.
DR Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 1.
DR Gene3D; 2.170.130.10; TonB-dependent receptor, plug domain; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR039426; TonB-dep_rcpt-like.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR PANTHER; PTHR30069:SF29; VITAMIN B12 TRANSPORTER BTUB; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR SUPFAM; SSF56935; Porins; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003357};
KW Receptor {ECO:0000313|EMBL:ACO01111.1}; Signal {ECO:0000256|SAM:SignalP};
KW TonB box {ECO:0000256|ARBA:ARBA00023077, ECO:0000256|RuleBase:RU003357};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..620
FT /note="Heme transporter BhuA"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002901252"
FT DOMAIN 49..155
FT /note="TonB-dependent receptor plug"
FT /evidence="ECO:0000259|Pfam:PF07715"
FT DOMAIN 211..594
FT /note="TonB-dependent receptor-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF00593"
SQ SEQUENCE 620 AA; 66824 MW; 9C93EBCAFCAC212F CRC64;
MHILKLSALL ASACAATLSP ALAQDGGDKD DGVTLDTIVV TPLRRASSLQ RSTSSVSVID
AADIERSAAP DLQSLLQTYS GISVKTNGGQ GSSADIYMRG MSSKQTVVLV NGVRTASATS
GSTALANIPL TSIERIEIAR GAHSSQYGAD AIGGVINIIT KQGGACGERA WCGSVSTGVS
HPWGGYASGS LQGRSSDGID YAVGAAFTGT QGYDFTTPEA FGHEPDDDGF LQGSFNFALS
KDFDWGKIYA DGLFSRGRNQ YDATAPAFNE ADSTAFTGKV GTRIDHTADW SSTVEFSTGI
DNSRNFRKGI EGSDRFETRR YGVFASTEKS FDTGKVSHVV TGGVEAYREK INTTIDYDET
GRDLAAVFGQ YSLEYDALRF DGGIRYDHNG QFGNVTTYNL GASYEILPDL VLRSSYATGF
RAPTFNELYY PGFANPDLQP EKSRSVEVGL NWQATASTSL DMALYQTRLS DAIMSTAPSY
IPYNIASAKV TGLEATLSHS FNEQWGIKGM VDLKRPVDED SGNDLPYRER FKAAAEVNFK
PVEKLDLTAR VLYGGSRYTN AKNTKKLGDY VTADFVALYS IDKQSQLKFS VENIFDKDYE
TSSGYVAPGR TITIGLTRNF
//
