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Database: UniProt/TrEMBL
Entry: C1B2P3_RHOOB
LinkDB: C1B2P3_RHOOB
Original site: C1B2P3_RHOOB 
ID   C1B2P3_RHOOB            Unreviewed;       224 AA.
AC   C1B2P3;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   19-FEB-2014, entry version 31.
DE   RecName: Full=Uracil-DNA glycosylase;
DE            Short=UDG;
DE            EC=3.2.2.27;
GN   Name=ung; OrderedLocusNames=ROP_65630;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Excises uracil residues from the DNA which can arise as
CC       a result of misincorporation of dUMP residues by DNA polymerase or
CC       due to deamination of cytosine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolyzes single-stranded DNA or mismatched
CC       double-stranded DNA and polynucleotides, releasing free uracil.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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DR   EMBL; AP011115; BAH54810.1; -; Genomic_DNA.
DR   RefSeq; YP_002783755.1; NC_012522.1.
DR   STRING; 632772.ROP_65630; -.
DR   EnsemblBacteria; BAH54810; BAH54810; ROP_65630.
DR   GeneID; 7745284; -.
DR   KEGG; rop:ROP_65630; -.
DR   PATRIC; 23230559; VBIRhoOpa21106_6644.
DR   eggNOG; COG0692; -.
DR   HOGENOM; HOG000229528; -.
DR   KO; K03648; -.
DR   OMA; IDESKHL; -.
DR   OrthoDB; EOG6MSS63; -.
DR   ProtClustDB; PRK05254; -.
DR   BioCyc; ROPA632772:GH0Q-6613-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.470.10; -; 1.
DR   HAMAP; MF_00148; UDG; 1.
DR   InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR   InterPro; IPR002043; Ura_DNA_glycsylse.
DR   InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR   PANTHER; PTHR11264; PTHR11264; 1.
DR   Pfam; PF03167; UDG; 1.
DR   SMART; SM00986; UDG; 1.
DR   SUPFAM; SSF52141; SSF52141; 1.
DR   TIGRFAMs; TIGR00628; ung; 1.
DR   PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; Glycosidase;
KW   Hydrolase.
FT   ACT_SITE     67     67       Proton acceptor (By similarity).
SQ   SEQUENCE   224 AA;  24196 MW;  D60113814D682BD9 CRC64;
     MAAPLSDLVE AGWAEALEPV SGRITEMGAF LRAEIADGRE YLPAGENVLR AFTHPFSEVK
     VLIVGQDPYP TPGHAVGLSF SVAPEVRPVP RSLGNIFTEY SKDLGYQTPT TGDLTPWSRQ
     GVLLLNRVLT VQPGLPASHR KKGWEAVTEQ AIRALVARPE PLVAILWGRD ASTLKPMLGD
     VPTIESAHPS PLSASRGFFG SRPFSRANEL LDSLGAEPVN WQLP
//
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