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Database: UniProt/TrEMBL
Entry: C1GUX9_PARBA
LinkDB: C1GUX9_PARBA
Original site: C1GUX9_PARBA 
ID   C1GUX9_PARBA            Unreviewed;      1021 AA.
AC   C1GUX9;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   07-JUN-2017, entry version 55.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PAAG_02452 {ECO:0000313|EMBL:EEH40397.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis;
OC   Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH40397.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH40397.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A.,
RA   Goldberg J., Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M.,
RA   Grynberg M., Gujja S., Heiman D.I., Henn M.R., Kodira C.D.,
RA   Leon-Narvaez H., Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L.,
RA   Morais F.V., Pereira M., Rodriguez-Brito S., Sakthikumar S.,
RA   Salem-Izacc S.M., Sykes S.M., Teixeira M.M., Vallejo M.C.,
RA   Walter M.E., Yandava C., Young S., Zeng Q., Zucker J., Felipe M.S.,
RA   Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G., Puccia R.,
RA   San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KN293996; EEH40397.2; -; Genomic_DNA.
DR   RefSeq; XP_015701694.1; XM_015844646.1.
DR   STRING; 502779.XP_002795746.1; -.
DR   EnsemblFungi; EEH40397; EEH40397; PAAG_02452.
DR   GeneID; 9098995; -.
DR   KEGG; pbl:PAAG_02452; -.
DR   EuPathDB; FungiDB:PAAG_02452; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002059};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EEH40397.2};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   DOMAIN      425    550       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      719    804       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      937   1020       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1021 AA;  116309 MW;  4D6DB352AAE95B28 CRC64;
     MDSDGGNEVD DVRRVADTEA DLDEKYPNRP RNHSPTLPFH DLFLTLFNPL NENKKRPTGP
     AVARRKVGPH GLGAAVHLSP QELRRDIIQR FISRWRKEVG NDVFPAFRLI IPGKDRDRAM
     YGLKEKAIGK LLVKVMKIDK NSEDGFSLLN WKVPGQTFAS RMAGDFAGRC FEIISKRPMR
     TEVGDMTIEE VNEQLDKLSA ASKEDEQVPI LEYFYRRMNP EELMWLIRII LRQMKVGATE
     RTLFNLWHPD AEALFSISSS LRRVCWELYN PNVRLEGDEA KVTLMQCFQP QLAQFQVQSF
     DRMIQRMSLA EDDPTFWIEE KLDGERMQLH MQTDDSIPGG KRFAFWSRKA KEYTYLYGNG
     LFDENGALTR HLQNAFADGV QSIILDGEMI TWDPEHDAIV PFGTLKTAAL AEQRNPFSTG
     QRPLFRIFDI LYLNGRALTR YILRDRRRAL EASVIPVHRR FEIHTYEIGR STADIEPLLR
     KVVAEASEGL VLKNPNSPYR LNERHDDWMK VKPDYMTEFG ESLDCVVIGG YYGSGRRGGA
     LSSFLCGLRV DGAHAKKGDK PTKCYSFCKV GGGFTAADYA NIRHHTDGKW MDWDPKTPPT
     EYIELGGGDA QHERPDVWIK PEDSVVLCIK AAQVTPSDQF RLGLTLRFPR FKRLRMDKDW
     QSALTVQEFM DFKSNVEKEV KEKELRFDDT SRPRHKKSTK KPLTVAGYEG GKKAAYASPS
     GKLFDGLNFF IMTESVQEPK KTKAQLEQLV KANGGKLYQT NTVAENTICI ADRRTVKVAS
     LQKNAKENVV RPSWLFDCLK QNEIDQGLPD LLIPLEPKHM FFTTADQEEE IAGNVDKYSD
     SYARDVDVSE LTKLLDEMPT VPNTTPSGIS QLESHIGHML DQTASFNNSS PGWLFKGLVI
     YFAAPRPASP SLCSSLRNDN LKEEKQRLPQ CLYLASNLVK FAGGQVITDD NDMTDPRITH
     IVIDSNIDDK TTTTTEISAI RRKIATRTGM NKRIPHLVGV EWVEESWREK TLVDEDRFAP
     K
//
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