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Database: UniProt/TrEMBL
Entry: C1GY57_PARBA
LinkDB: C1GY57_PARBA
Original site: C1GY57_PARBA 
ID   C1GY57_PARBA            Unreviewed;       474 AA.
AC   C1GY57;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   07-JUN-2017, entry version 55.
DE   SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:EEH41448.2};
GN   ORFNames=PAAG_03011 {ECO:0000313|EMBL:EEH41448.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis;
OC   Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH41448.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH41448.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A.,
RA   Goldberg J., Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M.,
RA   Grynberg M., Gujja S., Heiman D.I., Henn M.R., Kodira C.D.,
RA   Leon-Narvaez H., Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L.,
RA   Morais F.V., Pereira M., Rodriguez-Brito S., Sakthikumar S.,
RA   Salem-Izacc S.M., Sykes S.M., Teixeira M.M., Vallejo M.C.,
RA   Walter M.E., Yandava C., Young S., Zeng Q., Zucker J., Felipe M.S.,
RA   Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G., Puccia R.,
RA   San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; KN293999; EEH41448.2; -; Genomic_DNA.
DR   RefSeq; XP_015702023.1; XM_015844817.1.
DR   STRING; 502779.XP_002794466.1; -.
DR   EnsemblFungi; EEH41448; EEH41448; PAAG_03011.
DR   GeneID; 9097854; -.
DR   KEGG; pbl:PAAG_03011; -.
DR   EuPathDB; FungiDB:PAAG_03011; -.
DR   eggNOG; KOG1082; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   KO; K11419; -.
DR   OrthoDB; EOG092C2EWO; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002059};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EEH41448.2};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EEH41448.2}.
FT   DOMAIN      229    308       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      311    437       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      451    467       Post-SET. {ECO:0000259|PROSITE:PS50868}.
SQ   SEQUENCE   474 AA;  53549 MW;  D2E6D58F156CB5A8 CRC64;
     MVIDLTRDSS SEDDPRHGVE PEIRTPPHDE GLTLLQKFTR PSLRPGSSSS GGTMRNEWKS
     TASTNGAISS TLNGVLPSNK PPQPSFAVVV PSLGCDTGIK RRRLSSEDDS SSQANGVDPE
     FPNHHGLSSF YSVERRSKAL TYQPKQEVSR NRANIQIKQP AVRYHPFQKG HSDKDILSLY
     LKKLQRIQGP PVTLKIDPSD ASNIDFNFEF INEYKLQKGV KRVDPGFHVG CQCVGVCDSS
     SCYHLDRLPN EDEDEDEVSE HQIIPYQVGR DGKVVLRHEF FRKRAMIYEC SPLCTCLPSC
     LNRVVQKGRT LKLEIFRTDN RGFGLRSPEN IQAGQYIDRY LGEVITRKEA DAREAATPKN
     SASYLFQLDF FISAEENCYI VDGRKYGSIT RFMNHSCRPN CRMFPVSQYE AERNIFDMAF
     FAIKNIPAGT ELTFDYCPYS DKEGSKAVDP DAVKCLCGER TCRGQLWPNQ RKTM
//
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