ID C3N508_SULIA Unreviewed; 855 AA.
AC C3N508;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=aconitate hydratase {ECO:0000256|ARBA:ARBA00012926};
DE EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926};
GN OrderedLocusNames=M1627_1195 {ECO:0000313|EMBL:ACP55083.1};
OS Sulfolobus islandicus (strain M.16.27).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=427318 {ECO:0000313|EMBL:ACP55083.1, ECO:0000313|Proteomes:UP000002307};
RN [1] {ECO:0000313|EMBL:ACP55083.1, ECO:0000313|Proteomes:UP000002307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.16.27 {ECO:0000313|EMBL:ACP55083.1,
RC ECO:0000313|Proteomes:UP000002307};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023501};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
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DR EMBL; CP001401; ACP55083.1; -; Genomic_DNA.
DR RefSeq; WP_012718771.1; NC_012632.1.
DR AlphaFoldDB; C3N508; -.
DR GeneID; 84058521; -.
DR KEGG; sim:M1627_1195; -.
DR HOGENOM; CLU_013476_2_1_2; -.
DR Proteomes; UP000002307; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01586; AcnA_IRP; 1.
DR Gene3D; 6.10.190.10; -; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR006249; Aconitase/IRP2.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR01341; aconitase_1; 1.
DR PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR PANTHER; PTHR11670:SF54; CYTOPLASMIC ACONITATE HYDRATASE; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
DR PROSITE; PS01244; ACONITASE_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 62..529
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 663..779
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 855 AA; 95857 MW; 5D86C586791E9C66 CRC64;
MPSKFSYKGS EIYYYPLKEL EEKGYKISDL PYSIRILIEN VYRNLDGNKI TEEDLENITK
WKVGEELAFM PTRVVMQDYT GVPLLVDLAA MREKMIQLKK DPKMINPVVP ADLVIDHSVQ
VDYYGTVYSL EFNMKKEFER NLERYQFLKW AQGAFRNLRI VPPGKGIIHQ VNLEYLSTVV
TKAEVKGLLT AFPEVIIGTD SHTTMIEGLG ILGWGVGGLE AEAVLLGEPY YLNVPEVIGV
RLSGEIQEGV TPTDVVLYIT ELLRKKNVVS KFVEFFGPSL SLLSVPDRAT IANMAPEYGA
TAAYFPIDDV TVSYLELTNR DGEFVKKYSQ LQDLFYDDSR KIRYTDVVEV NLSKIEPAIA
GPRNPDERIV LREVKGKLSK EKKKKGKYVE DNAVVLAAIT SCTNTSNPTV MLGAGILAKK
AVEMGLRVPT YIKTSTAPGS PVVAEYLRET ELLPYLEALG FHLVGFGCTT CIGNAGPLPK
HVEEDIKENG IETYGVISGN RNFEGRINPL LKGTFLASPI LVVAYALAGR IDIDFYNDPI
GYDPNGKPVY LRDIWPSLKE IKAYMNMALK PELYKKNSNI FEGNELWNSL KTPQGDVYSW
DEKSTYIRLP PWYTEEKQEE LDDIVNARIL LLLGDKITTD HISPAGPITP DSPAGLYLKQ
FGVSDLNTYG ARRGNHEVML RGGFFNPKMK NLLVEKEGGY TVHFPDRRIA SVYEVAMQYK
KEGVPLVIVA GKQYGSGSSR DWAAKVTKLL GVKAVLAESF ERIHRSNLVA MGVIPIQIQD
WRSLGIKGDE TINIKGIKDL KPKKELVIEF VKSNGEKITT KGIARIDNNV ELTYVKKGGI
LNYVLEKFLE NERKS
//