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Database: UniProt/TrEMBL
Entry: C3XPG8_BRAFL
LinkDB: C3XPG8_BRAFL
Original site: C3XPG8_BRAFL 
ID   C3XPG8_BRAFL            Unreviewed;       928 AA.
AC   C3XPG8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=BRAFLDRAFT_119901 {ECO:0000313|EMBL:EEN69839.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|EMBL:EEN69839.1, ECO:0000313|Proteomes:UP000001554};
RN   [1] {ECO:0000313|EMBL:EEN69839.1, ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN69839.1,
RC   ECO:0000313|Proteomes:UP000001554};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN69839.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J.,
RA   Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J.,
RA   Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E.,
RA   Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y.,
RA   Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A.,
RA   Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; GG666451; EEN69839.1; -; Genomic_DNA.
DR   RefSeq; XP_002613830.1; XM_002613784.1.
DR   UniGene; Bfl.20221; -.
DR   STRING; 7739.JGI119901; -.
DR   GeneID; 7222688; -.
DR   KEGG; bfo:BRAFLDRAFT_119901; -.
DR   eggNOG; KOG4437; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   InParanoid; C3XPG8; -.
DR   KO; K10776; -.
DR   OMA; VFDCIYF; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.30.1740.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR031916; LIG3_BRCT.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR019406; Znf_C2H2_APLF-like.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF16759; LIG3_BRCT; 1.
DR   Pfam; PF10283; zf-CCHH; 1.
DR   Pfam; PF00645; zf-PARP; 1.
DR   SMART; SM01336; zf-PARP; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS00347; PARP_ZN_FINGER_1; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001554};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT   DOMAIN       13    105       PARP-type. {ECO:0000259|PROSITE:PS50064}.
FT   DOMAIN      492    626       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      848    928       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   928 AA;  103861 MW;  3CD9F7EE4715580B CRC64;
     MHRENKGLRT SRFCVEYAKQ GRAGCKKCKQ KIEKGLPRIG KIVPNFFHEG DGEMKQWYHV
     ACIFETFQRA RATTKKIEDA SDLEGWEDME DEEKQTILKL IKELESKAKS PKKKVVQATL
     STKGKIQSPT KKAASSATVS DDSPAAGPSS SSSASTSVSM TSPTPTPDID HKDNAFREFR
     RLCALIAEEP GYNAKTKLVS DFLKKGSNGD GFKGDTFLVV KLLLPGVVKR VYNLNNKQLL
     KHFANIFGVN LADMLTDLEL GDVSETVRKF FEESERCLPA KKSKLTIQEV DESLEILAQM
     TKEDDQMREL NKIAKKCTAN DLKVVVRLIK HDLRINAGAK HILEGLDPNA YPAFQASRNL
     ADVVERVVAN GCAPGMKKSL SIKANLMTPV LPMLAEACKS VEMAMRKCPN GMYAEIKYDG
     ERVQVHKQGN KFEYFSRSLK PVLPHKVAHF KDYIPKAFPH GSNMILDSEV LLVDTNTGNP
     LPFGTLGIHK KQQFSDAQVA LFVFDCIYFN GETLMDRPIS ERRKFLEDNM TVIPNRVVLS
     EYRYITEPGD LSDMIGRVIR DGLEGLVLKD TKSIYEPGKR HWLKVKKDYL EQGAMADTAD
     LVVLGAFYGT GNKGGLKSVF LMGVYDPDSD KWCTVTKCGN GHDDNTIAKL NKELAMVKIS
     KDMSKVPKWL KITKNLVPDF VCADPKKAPV WEITGAEFSK SEAHTADGIS IRFPRVTKIR
     DDKDWKSATN LKQLKHLFKT SKETSDIPDL LKGKGKSPRK PVKVKVEEED DDDDDDDDSN
     GGASSNGVTP IKGMKRKAEE DSPRTPKKSK PTCRYGATCY QTGKEHLDKF DHPTRKSPKK
     SNSAAKSVLP DVFCGIKLFL PDTVENYALL RRYFVAYDGD IVQDYAMSQA THVVEDPEQK
     NMNGKTDAQL VTVDWLWQCI KRKQLVPV
//
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