ID C3ZHM8_BRAFL Unreviewed; 252 AA.
AC C3ZHM8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Kinetochore protein SPC25 {ECO:0000256|ARBA:ARBA00013692, ECO:0000256|RuleBase:RU367150};
GN ORFNames=BRAFLDRAFT_122388 {ECO:0000313|EMBL:EEN48023.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN48023.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN48023.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN48023.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC -!- SIMILARITY: Belongs to the SPC25 family.
CC {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
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DR EMBL; GG666623; EEN48023.1; -; Genomic_DNA.
DR RefSeq; XP_002592012.1; XM_002591966.1.
DR AlphaFoldDB; C3ZHM8; -.
DR STRING; 7739.C3ZHM8; -.
DR eggNOG; KOG4657; Eukaryota.
DR InParanoid; C3ZHM8; -.
DR GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU367150};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU367150};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU367150};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367150};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Kinetochore {ECO:0000256|RuleBase:RU367150};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU367150};
KW Nucleus {ECO:0000256|RuleBase:RU367150}.
FT DOMAIN 182..249
FT /note="Chromosome segregation protein Spc25 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08234"
SQ SEQUENCE 252 AA; 28821 MW; 1EAFEC3DC28FFA3C CRC64;
MMLGTELQNL DGNLKQVQEA LLNKWTGDGL TKHLDEQKQK HAECMAQAKG EGSSCSNCYI
DWYPIITAKF FHPLMPADIS KLEDSVNSFK MQAETNRQAF QERIDLMQTA RQDIEKVKMQ
TEEMGQQEAE LRGMIGTSVK QIAKEKELIQ AQDKVTKQKM EELQKAVGFF KDRLGLKFRK
LDGGRLQFAF TVIDVKNPDR AFVFTLKVDS KYEVVDCDPK VADLDDLVAK LNTTNNLSAF
VQTMRKRFKQ LV
//
