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Database: UniProt/TrEMBL
Entry: C4JRH4_UNCRE
LinkDB: C4JRH4_UNCRE
Original site: C4JRH4_UNCRE 
ID   C4JRH4_UNCRE            Unreviewed;      1009 AA.
AC   C4JRH4;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   30-AUG-2017, entry version 51.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=UREG_05063 {ECO:0000313|EMBL:EEP80221.1};
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80221.1, ECO:0000313|Proteomes:UP000002058};
RN   [1] {ECO:0000313|Proteomes:UP000002058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CH476617; EEP80221.1; -; Genomic_DNA.
DR   RefSeq; XP_002584374.1; XM_002584328.1.
DR   STRING; 336963.XP_002584374.1; -.
DR   EnsemblFungi; EEP80221; EEP80221; UREG_05063.
DR   GeneID; 8443373; -.
DR   KEGG; ure:UREG_05063; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   InParanoid; C4JRH4; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002058};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT   DOMAIN      417    542       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      723    796       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      886    987       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1009 AA;  115751 MW;  2049706A9DECD153 CRC64;
     MDGLNGPKGE TEQELDEKYP NRPRNHHPTL PFHDLFLDLF NPLNENKKRP AGSTVARRKL
     GPHGGQQTLS PQELRRDIIQ RFISKWRNEV GDDIYPAFRL IIPEKDRDRA MYGLKEKTIG
     KLLVKIMKID KNSEDGFNLL NWKLPGQSMA SRMAGDFAGR CYEVISKRPM RTEVGNMTVQ
     EVNEKLDLLA AANKEDEQLP ILEDFYRKMN PEELLWLIRI ILRQMKVGAT ERTFFEIWHP
     DAETLFSISS SLRRVCWELY NPNVRLEDEE TGVTLMQCFQ PQLAQFQMHS FQRMIEKMRL
     SPEDPSFWIE EKMDGERMQL HMMSDDSITG GKRFKFWSRK AKDYTYLYGN GFYDENGALT
     RHLKDAFADG VQNIILDGEM ITWDPEQDAP VPFGTLKTAA LSEQRNPFSA TGQRPLFRAF
     DILYLNDKAL TRYTLRDRRK ALEASIKPVH RRFEIHTYEV GYSAAHIEPQ LRKVVAEASE
     GLVLKNPDSP YRLNERHDDW MKVKPEYMTE FGESLDCVVI GGYYGSGKRG GALATFLCGL
     RVDEAQIRQG ANPMKCYSFC KVGGGFTAAD YANVRHHTDS KWKDWDPKKP PTEFIELAGG
     DAQYERPDVW IRPDESVVLC VKASSVTPSD QFRLGLTVRF PRFKRLRMDK TWESALSIQE
     FMDLKSNAER EQKEKEFKID NSRKRKPKRT TKKPLTIAGY DENKKAEFDV SDQIFTSKSD
     SLVVMTDALE PEKKSKLELE KLIKANGGKI YQTNTAASNT ICIAERRTVK VASIQKAAKE
     NIVRPSWLLD CIKQNEADLG LPDLLLPLEP RHMYFTVKGQ EQEISSNVDQ YSDSYVRDTT
     TKELTKLLAS MPAISNLSAS RISKIEDQMQ SRHEQEGTFH DLPGWLFKNQ VLYFSQSRSS
     SDSKVSSSRL ASNIARFAGA SLVSKPDDKR VTHIILDKDS RSADVSALRS SISKRVGAGR
     IPHIVTVEWI NESWKAKTLL DEEQLLKGVH FEFRKVCIDA FYRSHISVS
//
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