ID C4KRQ9_BURPE Unreviewed; 263 AA.
AC C4KRQ9;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 03-APR-2013, entry version 27.
DE RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase;
DE EC=2.7.7.38;
DE AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase;
GN Name=kdsB; ORFNames=GBP346_A0851;
OS Burkholderia pseudomallei MSHR346.
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=536230;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MSHR346;
RA Harkins D.M., Brinkac L.M., Rogers Y.C., Detter J.C., Munk A.C.,
RA Bruce D.C., Keim P., Sims D.R., Brettin T.S.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates KDO (a required 8-carbon sugar) for
CC incorporation into bacterial lipopolysaccharide in Gram-negative
CC bacteria (By similarity).
CC -!- CATALYTIC ACTIVITY: CTP + 3-deoxy-D-manno-octulosonate =
CC diphosphate + CMP-3-deoxy-D-manno-octulosonate.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-
CC octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from
CC 3-deoxy-D-manno-octulosonate and CTP: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the KdsB family.
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DR EMBL; CP001408; ACQ98250.1; -; Genomic_DNA.
DR RefSeq; YP_002895575.1; NC_012695.1.
DR ProteinModelPortal; C4KRQ9; -.
DR SMR; C4KRQ9; 6-257.
DR STRING; 536230.GBP346_A0851; -.
DR EnsemblBacteria; ACQ98250; ACQ98250; GBP346_A0851.
DR GeneID; 7887625; -.
DR KEGG; bpr:GBP346_A0851; -.
DR PATRIC; 32570893; VBIBurPse130472_0786.
DR eggNOG; COG1212; -.
DR HOGENOM; HOG000007602; -.
DR KO; K00979; -.
DR ProtClustDB; PRK05450; -.
DR BioCyc; BPSE536230:GHVQ-911-MONOMER; -.
DR UniPathway; UPA00030; -.
DR UniPathway; UPA00358; UER00476.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IEA:HAMAP.
DR GO; GO:0033468; P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019294; P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00057; CMP_KDO_synth; 1; -.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR004528; KdsB.
DR PANTHER; PTHR21485:SF4; PTHR21485:SF4; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR TIGRFAMs; TIGR00466; kdsB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Lipopolysaccharide biosynthesis; Nucleotidyltransferase;
KW Transferase.
SQ SEQUENCE 263 AA; 28758 MW; 5A4CC93F0C4E2AEA CRC64;
MTSPLPFVAV VPARLASTRL PNKPLADLGG KPMVVRVAER AREAGAQQVL VASDAQRVLD
AVREHGFDAV LTRADHPSGT DRLAEVAAKL GFDDDTIVVN VQGDEPLIDP QLVRDVASHL
AAHPSCAIAT AAHPIHEAHE VFNPNYVKVV LDAHGVALYF SRAPIPWSRD AYLPHWPNVA
AMPAPTCPVY RHIGLYAYRA RFLRTYPTLA QAPIEAAEQL EQLRAMWHGE RIAVRVTEHA
PEAGIDTPAD LERVQALFRS RAK
//
