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Database: UniProt/TrEMBL
Entry: C4R4M0_KOMPG
LinkDB: C4R4M0_KOMPG
Original site: C4R4M0_KOMPG 
ID   C4R4M0_KOMPG            Unreviewed;       488 AA.
AC   C4R4M0;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 55.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   OrderedLocusNames=PAS_chr3_1192 {ECO:0000313|EMBL:CAY70506.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia
OS   pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70506.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY70506.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; FN392321; CAY70506.1; -; Genomic_DNA.
DR   RefSeq; XP_002492685.1; XM_002492640.1.
DR   STRING; 644223.XP_002492685.1; -.
DR   EnsemblFungi; CAY70506; CAY70506; PAS_chr3_1192.
DR   GeneID; 8199586; -.
DR   KEGG; ppa:PAS_chr3_1192; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   HOGENOM; HOG000162670; -.
DR   InParanoid; C4R4M0; -.
DR   KO; K00844; -.
DR   OMA; ERQFFRA; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000314};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    217       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      223    462       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   488 AA;  54248 MW;  B8ED50BD2E8A18E5 CRC64;
     MVHLGAKKPQ HRKLSPELRK AYKEVEAQFV VSTPRLKQIV DQFVAELKEG LKSSSSNIPM
     LPTWVMDFPT GEETGDYLAI DLGGTNIRVI LVRLLGNRKF DTIQSKYVLP KWIRTSTSNE
     LWLFIAQCVK TFIDEEFDYR ESPEDPIPLG FTFSYPAFQS RINSGVLQRW TKGFDIPDVE
     GHDVVPMLQD ALESLGLSVV VVALINDTTG TLVASTYTDP ETKMGLIFGT GVNGAYYDTI
     SSVSKISNAL PPDIQEDASM AINCEYGAFD NNISVLPRTK YDDTIDLESP RPGQQSYEKM
     ISGYYLGELL RLVLVDLHHQ GHIFKGQTIG KLNEPFIMDT SFPARIEEDP FENLCETGEL
     FNSLGIETTV PERELIRRIC ELIGTRAARL SVCSIAAICK KRGYKKAHCA ADGSVFTRYP
     YFPDRAARAL RDIFQWGHST PDLVTVVPAE DGSGVGAAII AALTKQRMAN GESVGLDEYH
     PQDGKDSN
//
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