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Database: UniProt/TrEMBL
Entry: C4R5E5_KOMPG
LinkDB: C4R5E5_KOMPG
Original site: C4R5E5_KOMPG 
ID   C4R5E5_KOMPG            Unreviewed;       932 AA.
AC   C4R5E5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   25-OCT-2017, entry version 61.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   OrderedLocusNames=PAS_chr3_0732 {ECO:0000313|EMBL:CAY70781.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia
OS   pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70781.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY70781.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; FN392321; CAY70781.1; -; Genomic_DNA.
DR   RefSeq; XP_002492960.1; XM_002492915.1.
DR   ProteinModelPortal; C4R5E5; -.
DR   STRING; 644223.XP_002492960.1; -.
DR   EnsemblFungi; CAY70781; CAY70781; PAS_chr3_0732.
DR   GeneID; 8200427; -.
DR   KEGG; ppa:PAS_chr3_0732; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000093622; -.
DR   InParanoid; C4R5E5; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 3.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000314};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:CAY70781.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT   DOMAIN      380    509       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      662    758       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      809    930       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   932 AA;  107903 MW;  50E13B7042003F1F CRC64;
     MSEELKEPKN RAPLPNFSHL VYDLFEKLDT CVKSPHIPES LRSRKTKIIE QFVQKWRFEI
     GDNIYPASRL IFPNLDKRHY NIKDFTLIKF ILDIFQVPKD SEDTKILRNW KGKYENRMRS
     NKNDLAQLLT GVIKARRGAV LDRPEISIDR LNELLDTMTR PETKPSDQKK ILTEIFNHVD
     NIELKWFLRI LLKRKLMGGM DFTFFRQWHP DAVELLQLVN DLKTVFWELT DRLIPLPEAG
     RVIRVGRAFR PQLAMRPNRT YDQIATLFDN NFYIEDKLDG ERILIHISLN DTTQQHEFKY
     FSRSGTDYTY LYGSNYEEGA FSPFIKGCFI DLKDDTKEIR SMVLDGEFLV YDNKRNVILP
     FGALKSASLT RLMEEKNDSE DSQETQVYFV VYDLVFLNGT SFQDKALKVR RNLLNKILAN
     PIPNRIEVIK YTEGHVGSDI EAAMRSAIHD NREGIVVKNP KSKYYIASRN LNWVKIKPEY
     LEEFGENIDL IILGKRKGLK NAYICGLRES LGNDRYRFLS LARIANGFTG QMYEEIEHSL
     GSKWVNIRKT QPPYPYIDLG EISSMVDYWV DPKESVVLEI KARSIDIGDG GKRYAAGTTL
     YNAYCVRIRS DKDFLSCSTF ADYKEIKTSK SRHKTEKTHS LMSKRKRTIV TEPILAKQSV
     SSKSSIFKDY IFYVLSDMLG EKRYSIAQLE ALLVENGGRI TKNDCVALAD GERLVLLSDK
     ITFKVTEYFN KGLNVFRPGF ILKCLQLKTI IPLQINDILL ADESLIEKVK KNSDRFGDSY
     TSPIDRKELR MLMKGIPKIK LEHPLKFPLL YNLFKGLKFY IARPCYRSPF LTNVMSPYLL
     EVIVILGGFL TTDIFQCSFI IVDTSTTFNY SWLTEEATIQ DEVGSLRKKL GDDLPIVKGV
     LDKVPRIVEK EWVFKCIQEG TIVAADGYNY IG
//
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