ID C5C7C4_MICLC Unreviewed; 507 AA.
AC C5C7C4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=EPTC-inducible aldehyde dehydrogenase {ECO:0000313|EMBL:SQG48041.1};
DE EC=1.2.1.3 {ECO:0000313|EMBL:ACS31612.1, ECO:0000313|EMBL:SQG48041.1};
DE SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:ACS31612.1};
GN Name=thcA {ECO:0000313|EMBL:SQG48041.1};
GN OrderedLocusNames=Mlut_21440 {ECO:0000313|EMBL:ACS31612.1};
GN ORFNames=NCTC2665_00814 {ECO:0000313|EMBL:SQG48041.1};
OS Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Micrococcus.
OX NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS31612.1, ECO:0000313|Proteomes:UP000000738};
RN [1] {ECO:0000313|EMBL:ACS31612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS31612.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT "Complete sequence of Micrococcus luteus NCTC 2665.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX PubMed=19948807; DOI=10.1128/JB.01254-09;
RA Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT free-living actinobacterium.";
RL J. Bacteriol. 192:841-860(2010).
RN [3] {ECO:0000313|EMBL:SQG48041.1, ECO:0000313|Proteomes:UP000248985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG48041.1,
RC ECO:0000313|Proteomes:UP000248985};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; CP001628; ACS31612.1; -; Genomic_DNA.
DR EMBL; LS483396; SQG48041.1; -; Genomic_DNA.
DR RefSeq; WP_012751114.1; NZ_WBMF01000102.1.
DR AlphaFoldDB; C5C7C4; -.
DR SMR; C5C7C4; -.
DR STRING; 465515.Mlut_21440; -.
DR EnsemblBacteria; ACS31612; ACS31612; Mlut_21440.
DR KEGG; mlu:Mlut_21440; -.
DR PATRIC; fig|465515.4.peg.2070; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_11; -.
DR OMA; VWTRDAH; -.
DR Proteomes; UP000000738; Chromosome.
DR Proteomes; UP000248985; Chromosome 1.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000000738}.
FT DOMAIN 28..494
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 507 AA; 55502 MW; 0A908B7274C3DC31 CRC64;
MTVYAFPGTE GAKVEFKSRY EHFIGGEWTP PVKGQYFENV TPVTGKVFCE VARGTAEDID
AALDAAWKAA PAWGATSPAE RALVLHRIAD RMEENLEMLA VAETWDNGKA VRETLNADVP
LAIDHFRYFA GAIRAQEGRL SQLDEDTVAY HFHEPLGVVG QIIPWNFPLL MGVWKLAPAL
AAGNAVVIKP AEQTPASIMV FIELIADLLP AGVVNVVNGF GLEAGKPLAQ SPRIRKIAFT
GETTTGRLIM QYASENIIPV TLELGGKSPN VFFEDVMAAD DAYWDKAQEG FTLFALNQGE
VCTCPSRALV QESIAEKFLD AVVERTSRIV TGNPLDTDVM MGAQVSNDQL EKIMSYLDIG
RQEGAEVLIG GARAEMEGEL AGGYYVQPTI FRGDNSMRIF QEEIFGPVVS TTTFTDFDDA
MRIANDTLYG LGAGVWSRNG NTAYRAGRAI QAGRVWVNNY HAYPAHAAFG GYKSSGIGRE
NHLMMLDHYQ QTKNLLVSYS EDKLGFF
//