ID C5CUE9_VARPS Unreviewed; 1776 AA.
AC C5CUE9;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ACS20362.1};
GN OrderedLocusNames=Vapar_3746 {ECO:0000313|EMBL:ACS20362.1};
OS Variovorax paradoxus (strain S110).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS20362.1};
RN [1] {ECO:0000313|EMBL:ACS20362.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S110 {ECO:0000313|EMBL:ACS20362.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA Leadbetter J.R., Spain J.C., Han J.I.;
RT "Complete sequence of chromosome 1 of Variovorax paradoxus S110.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001635; ACS20362.1; -; Genomic_DNA.
DR STRING; 543728.Vapar_3746; -.
DR KEGG; vap:Vapar_3746; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_9_4; -.
DR OrthoDB; 6297021at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 600..675
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1666..1741
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1776 AA; 192109 MW; 5A270523377B60B1 CRC64;
MEKNTQAQQA PISPRPTNFV AHLRALADAR RDDIWLTVVS AVDGTERAEP ISYGTFERRV
RALAARLQQQ FAKKGERALV MLDNGDHYAV SMLACFYAGV IAVPVFPPES ARPQHLARLT
GIAADSQARC VLTSEAMARA MNAASAGLRQ FGDAHIVAVD TVDISLADAW TPFEPADGDV
AFLQYTSGST SAPKGVIVTH GNLMANEEAI QRSMGVGPGD SFVSWAPLYH DMGLIGGLLQ
PLYSGIPLVL TSPGYFLERP VRWLELISRH RATLSGGPDF AYRLCLERVK DAQLAPLDLS
SWRVAYTGAE PVRADTEIEF ISRFASAGFD AAAVYPCYGL AEATLFVTGG RRGGGLVAPT
FSATGLASGV GAPADEGAAL VGCGNVAPGH RIEIVDAESL SAAAPGKIGE IWTCGPSIGH
GYWGKERETR ETFVERNGQR WLRTGDLGFM HEGQLYVTGR IKDLIIVRGH NIYPQDIERL
IEAEVDAVRK GRVAVFATQG PGGEGIGVAA EVSRSMQKLV PAAVLVDALG AAVSEVFGET
LSVVLLLNPG GMPKTTSGKL QRSACRAGWL DGSADAYAVY QHGAFVRGGL GEAVAEAPLD
EVEQAVAAIW REVCKHGDDR PLGRDAHFFN RGGSSLTATQ AAARIGARWQ IDFPARRLFE
QPRLRDCASA IRELQLQGVR PQPAPIAVLS AERRLLPLPL SHAQERQWFL WQIDPESAAY
HVSGALRLAG ALRVDALQAA FDGLVARHES LRTVFSAGAD GSVEQWIRPG GSVPLALVDL
RGAEAEADAR LDEATRRLKA QPFDLTQDPL LRAALIRTAD EVHVLAVVMH HIVSDGASMQ
LLIDELAAGY AAHLKGDTVR LAAPRIQYAD HALWQREWLA AGEGERQLAW WRTQLGDTHT
VLELRTDHPR KPQAGYGAAS HAFELPASLL ARLRKAADGG GATLFMVLLA GFQALLHRYT
GQEDIRIGAP FANRNRVEAE GVVGLFVNTL VLRNPIHGRL GASRVLAQAR DAVLGAQAHQ
DVPFEQLVQM LQPERSLSRT PLFQVMFNHL FEDYRSLGQL PGIAAQDHAL PDLAAQFELT
LEARERPGGQ LSLALIYAAE LFEPGTMARM ASHYVAVLQA LVERPHQPIG DIELLGAPEQ
AQLAQWGVNG HREPQPEPVH RMIERQARMQ PDATALLFAD ESLGFAELNR RANRLAHRLI
ALGVKPEVLV GIAMERSVEM VVAILGVLKA GGAYVPLDPE YPAERLAYMV QDSGIGLLLT
QRSVAYCVAN CVPDRRALTV LEVDAADLGA EPESDPQVGL HIENLAYVIY TSGSTGKPKG
AAIRHSALHS CMAWMQGIYK LTRADTVLHK APFGFDVSVW ELFWPMTSGA RLVVANPGDH
RDPARLVELI QRHQVTTLNF VPSMLQAFLA HKGIEASTRL RHIICGGEAM PAETQKETLE
RLHGAGLQNL YGPTETTIHV THWACRNDGQ SQVPIGKPIS HTSAHVLDAE LNLVPQGVAG
ELYLGGISLA RGYLKRAGLS AERFVADPFD SAGGGRLYRT GDLVRWNGEG QLEYLGRIDH
QVKIRGFRIE LGEIEAELLA QPAVREAVVV ARDGPAGARL VGYLAPHAGE AIDTAALKER
LAQVLPDYMV PRAFEVLDAL PLNANGKVDR KALPEPALAS GQAYEAPQGH VAQTVAAVWS
EVLQVAQVGL HDNFFDLGGH SLLLIRAHRL LEDRLHTAIP VVNLFKYPTV QSLVQWLEQA
PARAAASASA AAASDDRALR QRAAMLQRRK AAERVN
//
