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Database: UniProt/TrEMBL
Entry: C5DEQ7_LACTC
LinkDB: C5DEQ7_LACTC
Original site: C5DEQ7_LACTC 
ID   C5DEQ7_LACTC            Unreviewed;       951 AA.
AC   C5DEQ7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   25-OCT-2017, entry version 56.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   OrderedLocusNames=KLTH0C11286g {ECO:0000313|EMBL:CAR22268.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR22268.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR22268.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CU928167; CAR22268.1; -; Genomic_DNA.
DR   RefSeq; XP_002552706.1; XM_002552660.1.
DR   ProteinModelPortal; C5DEQ7; -.
DR   STRING; 381046.XP_002552706.1; -.
DR   EnsemblFungi; CAR22268; CAR22268; KLTH0C11286g.
DR   GeneID; 8291592; -.
DR   KEGG; lth:KLTH0C11286g; -.
DR   HOGENOM; HOG000093622; -.
DR   InParanoid; C5DEQ7; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002036; Chromosome C.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN      383    515       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      685    783       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      843    950       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   951 AA;  108867 MW;  6F40D1836C666F1E CRC64;
     MDGNGKCPSE TDTSKISENE PHNFAPSPDF RWLCEELFHR LDAINEHRQE LGKAVTVKRV
     EIITCFIKLW RTTVGDDFFP ALRLMFPYRD PRAYHIKDFT LIKAVCKALN LSRDSLTERR
     LLNWKQYAGR GTSLSKFCVQ EISKRRKEPL PERQLTIDGL NEKLDELAKE ASGKKAWGTT
     GLSESHSFQF CLKNLSFLEL RYFFDIVLKN RVIGGLEHKF LACWHPDAQI YLGVVTDLKI
     LSKKLWNPSV RLDKRDLSIN IGHAFAPHLA KRLHVSYERI CSKLKHDFIL EEKMDGERIQ
     LHYVNGGSVL KFLSRRGIDF SHLYGQEVAR GVISQYLKLK SDVRDCVLDG EMVSYDKKRK
     IILPFGIVKS AAVDELINSE VGNENDGYRP LYMVFDLVYL NGVSLTKVPL HIRKEYLKEI
     LSPVPDVVEI LKGIRACDAK AIKNFMQRAI EMGSEGVIVK QASSTYEVGA RNDHWVKIKP
     EYFEDLGETM DLVVIGRDPG KKDSLMCGLL VSDSEHILEN FGPIEHGKEG DPIIKCVSFC
     NVANGVSDEE FKEINRKTRG SWVSYKEKPP PLSLLEFGSK IPVEWIDPKN SVVIEVKARS
     VENSEYSSKR YRAGSTLHSA YCRRIRNDKD WTTCTSVAQY QQAKAAHNYH RYKRKVHQVS
     PRRKRNVHEI FEYCAGEAKS ELDTEGSSIF EGLHFYILSD YVTSQRRRYE RGMVAAKVVK
     HGGLIVKNID MRPEHLSYLR IVSGKTTIEC RNLVNRGYDI IDPCWIFDCI SAGFQLGIEP
     KHCFQTSRRL LDNSRQRVDQ YGDSFSRPLD TTEFQQLFKF FCSSPSDFSS RISSMLQDDL
     DEAPLFLLQR FKIYVLAADL IPQQFSILRR KIELYGGVVS ETLEGANLVL VPSALSTART
     AYYVQELRQK IAGNAFAGNT NTRIPHIVRS EWLDTCTTEQ CLVPEEDFSS I
//
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