ID C5M519_CANTT Unreviewed; 440 AA.
AC C5M519;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 06-MAR-2013, entry version 24.
DE RecName: Full=Mannose-6-phosphate isomerase;
DE EC=5.3.1.8;
GN ORFNames=CTRG_01997;
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC Candida.
OX NCBI_TaxID=294747;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L.,
RA Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S.,
RA Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J., Harris D.,
RA Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E.,
RA Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J.,
RA Santos M.C., Schmitzberger F.F., Sherlock G., Shah P.,
RA Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I.,
RA Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W.,
RA Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC phosphate.
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC phosphate: step 1/2.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC family.
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DR EMBL; GG692396; EER35135.1; -; Genomic_DNA.
DR RefSeq; XP_002547690.1; XM_002547644.1.
DR GeneID; 8296353; -.
DR KEGG; ctp:CTRG_01997; -.
DR KO; K01809; -.
DR OrthoDB; EOG4TF3V5; -.
DR UniPathway; UPA00126; UER00423.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.10; -; 3.
DR InterPro; IPR001250; Man6P_Isoase-1.
DR InterPro; IPR016305; Mannose-6-P_Isomerase.
DR InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin.
DR PANTHER; PTHR10309; PTHR10309; 1.
DR Pfam; PF01238; PMI_typeI; 1.
DR PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR PRINTS; PR00714; MAN6PISMRASE.
DR SUPFAM; SSF51182; RmlC_like_cupin; 1.
DR TIGRFAMs; TIGR00218; manA; 1.
DR PROSITE; PS00965; PMI_I_1; 1.
DR PROSITE; PS00966; PMI_I_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Zinc.
SQ SEQUENCE 440 AA; 48737 MW; B8456D20F0A91C9A CRC64;
MATDKLFRIQ CGYQNYDWGK IGSTSAVAQF AHNSDPSVVV DESKPYAELW MGTHPSVPSK
AIDLGNETLR DLVNANPKQY LGDSIIKKFG DSKGLPFLFK VLSIEKVLSI QAHPDKELGA
ILHAQDPKNY PDDNHKPEMA IAITEFEAFC GFKPLDQLAR SLTNIPELNS IIGQELVDEF
VNGIVVNAEP ETEDDKNNKK LLQKVFGKLM NSECSDLTQK AADLVVRTEQ EPELFKDIDP
RLPALVHRLN SQFPNDVGLF CGCLLLNHVH LNPGEAIFLQ AKEPHAYITG DIIECMAASD
NVVRAGFTPK FKDVENLVEM LTYSSVSIEK QKMPLQDFPR STGTAVKSVL YDPPIEEFSV
LQTIFDKTKG GKQTMEGVQG PSIIIGTHGN GSIQIKGDDS TRQKLDTGYV FFVAPDVAIE
LIGDENQEQD FTTYRAFVEA
//
