ID C6A488_THESM Unreviewed; 393 AA.
AC C6A488;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=2-ketoisovalerate:ferredoxin oxidoreductase (VOR) subunit alpha {ECO:0000313|EMBL:ACS90433.1};
DE EC=1.2.7.1 {ECO:0000313|EMBL:ACS90433.1};
GN OrderedLocusNames=TSIB_1382 {ECO:0000313|EMBL:ACS90433.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS90433.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS90433.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC chain. {ECO:0000256|ARBA:ARBA00011595}.
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DR EMBL; CP001463; ACS90433.1; -; Genomic_DNA.
DR RefSeq; WP_015849651.1; NC_012883.1.
DR AlphaFoldDB; C6A488; -.
DR STRING; 604354.TSIB_1382; -.
DR GeneID; 8096384; -.
DR KEGG; tsi:TSIB_1382; -.
DR eggNOG; arCOG01608; Archaea.
DR HOGENOM; CLU_002569_5_0_2; -.
DR OrthoDB; 372068at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR32154:SF0; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01855; POR_N; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ACS90433.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 15..240
FT /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT pyrimidine binding"
FT /evidence="ECO:0000259|Pfam:PF01855"
FT DOMAIN 263..366
FT /note="Pyruvate:ferredoxin oxidoreductase core"
FT /evidence="ECO:0000259|Pfam:PF17147"
SQ SEQUENCE 393 AA; 44122 MW; 92098FE527879357 CRC64;
MPKKVISGNY AAAYAAKHAR VEVVAAYPIT PQTSIIEKIA EFIANGEVEN LEYVPVESEH
SAMAACIGAS AAGARTFTAT SAQGLALMHE MLHWAAGARL PVVMVDVNRA MAPPWSVWDD
QTDSLAQRDT GWLQFYAENN QEVYDGVLMA FKIGEHEKVN LPVMVIESAF ILSHTYDIVD
MLEQEEVDEF LPPRKPLYSL TDFDNPFSIG ALGTPADYYE FRYKIAKAME EAKKIIKEVG
KEFGEKFGRD YSQMIELYKT EDADIVFMGM GSLMGTVKEA VDIFRSEGYK VGAAKVRWFR
PFPREELYEL AKSVEGIAVL DRNFSFGQEG ILFNEAKGIL YNTDANPIMK NYIVGLGGRD
LTVNDVRKIA SNMKKIIEKG ELDKEIDWYH LKR
//
