ID C6DNE9_MYCTK Unreviewed; 421 AA.
AC C6DNE9;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE RecName: Full=Aspartokinase;
DE EC=2.7.2.4;
GN OrderedLocusNames=TBMG_03753;
OS Mycobacterium tuberculosis (strain KZN 1435 / MDR).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=478434;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KZN 1435 / MDR;
RA Murray M., Pillay M., Borowsky M.L., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J.,
RA Yandava C., Haas B., Nusbaum C., Galagan J., Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis strain KZN 1435.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC aspartate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway; L-homoserine from L-aspartate: step 1/3.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 1/5.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
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DR EMBL; CP001658; ACT26861.1; -; Genomic_DNA.
DR RefSeq; YP_003033756.1; NC_012943.1.
DR ProteinModelPortal; C6DNE9; -.
DR STRING; 478434.TBMG_03753; -.
DR EnsemblBacteria; ACT26861; ACT26861; TBMG_03753.
DR GeneID; 8164565; -.
DR KEGG; mtb:TBMG_03753; -.
DR PATRIC; 18165731; VBIMycTub122270_4148.
DR eggNOG; COG0527; -.
DR HOGENOM; HOG000293093; -.
DR KO; K00928; -.
DR OMA; SVDMIIQ; -.
DR ProtClustDB; PRK06635; -.
DR BioCyc; MTUB478434:GH8E-3880-MONOMER; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1160.10; -; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase_dom.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 1.
DR PIRSF; PIRSF000726; Asp_kin; 1.
DR SUPFAM; SSF53633; Aa_kinase; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Kinase; Transferase.
SQ SEQUENCE 421 AA; 44471 MW; 0F909EB82B5BAED6 CRC64;
MALVVQKYGG SSVADAERIR RVAERIVATK KHGNDVVVVV SAMGDTTDDL LDLAQQVCPA
PPPRELDMLL TAGERISNAL VAMAIESLGA HARSFTGSQA GVITTGTHGN AKIIDVTPGR
LQTALEEGRV VLVAGFQGVS QDTKDVTTLG RGGSDTTAVA MAAALGADVC EIYTDVDGIF
SADPRIVRNA RKLDTVTFEE MLEMAACGAK VLMLRCVEYA RRHNIPVHVR SSYSDRPGTV
VVGSIKDVPM EDPILTGVAH DRSEAKVTIV GLPDIPGYAA KVFRAVADAD VNIDMVLQNV
SKVEDGKTDI TFTCSRDVGP AAVEKLDSLR NEIGFSQLLY DDHIGKVSLI GAGMRSHPGV
TATFCEALAA VGVNIELIST SEIRISVLCR DTELDKAVVA LHEAFGLGGD EEATVYAGTG
R
//
