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Database: UniProt/TrEMBL
Entry: C6E8Y5_GEOSM
LinkDB: C6E8Y5_GEOSM
Original site: C6E8Y5_GEOSM 
ID   C6E8Y5_GEOSM            Unreviewed;       947 AA.
AC   C6E8Y5;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   19-MAR-2014, entry version 44.
DE   RecName: Full=UvrABC system protein A;
DE            Short=UvrA protein;
DE   AltName: Full=Excinuclease ABC subunit A;
GN   Name=uvrA; OrderedLocusNames=GM21_0189;
OS   Geobacter sp. (strain M21).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=443144;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M21;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Lovley D.;
RT   "Complete sequence of Geobacter sp. M21.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding
CC       protein. A damage recognition complex composed of 2 UvrA and 2
CC       UvrB subunits scans DNA for abnormalities. When the presence of a
CC       lesion has been verified by UvrB, the UvrA molecules dissociate
CC       (By similarity).
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA
CC       family.
CC   -!- SIMILARITY: Contains 2 ABC transporter domains.
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DR   EMBL; CP001661; ACT16274.1; -; Genomic_DNA.
DR   RefSeq; YP_003020032.1; NC_012918.1.
DR   STRING; 443144.GM21_0189; -.
DR   EnsemblBacteria; ACT16274; ACT16274; GM21_0189.
DR   GeneID; 8135492; -.
DR   KEGG; gem:GM21_0189; -.
DR   PATRIC; 22014880; VBIGeoSp56140_0196.
DR   eggNOG; COG0178; -.
DR   HOGENOM; HOG000050449; -.
DR   KO; K03701; -.
DR   OMA; PDVYVQC; -.
DR   OrthoDB; EOG6QK4PS; -.
DR   ProtClustDB; CLSK829225; -.
DR   BioCyc; GSP443144:GHKM-193-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006200; P:ATP catabolic process; IEA:GOC.
DR   GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IEA:GOC.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1490.20; -; 2.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; DNA-binding; Excision nuclease; Metal-binding;
KW   Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
FT   DOMAIN      316    594       ABC transporter 1 (By similarity).
FT   DOMAIN      614    941       ABC transporter 2 (By similarity).
FT   NP_BIND      33     40       ATP (By similarity).
FT   ZN_FING     259    286       C4-type (By similarity).
FT   NP_BIND     645    652       ATP (By similarity).
FT   ZN_FING     744    770       C4-type (By similarity).
SQ   SEQUENCE   947 AA;  104633 MW;  6329F183A6A5477C CRC64;
     MATDKIIIKG ACEHNLKCID VEIPRDKLVV ITGISGSGKS TLAFDTIYAE GQRRYVESLS
     AYARQFLEQM EKPDVESIEG LSPAISIEQK TTSKNPRSTV GTVTEIYDYL RLLFARIGKP
     HCYNCGRIIT SQTVSQMVDQ IAALPQGAKL TLLSPIVRGR KGEYKKELTQ FRKDGFARVV
     VDGETHDLSE EITLDKKKKH DIDIVVDRLV VKPGIEKRLA DSLETALSHA EGIVKVALTP
     DADRGIKEET LLFSESAACI ECGISYPEMT PRMFSFNNPY GACPDCTGLG TRMYLDTNLV
     VPDHDLTLAE GAVAPWETRF SGWYQQTLAA LGKSYGFDLH TPYKQLSKKA KDVILNGSGG
     ELVDFWWVDD AGKRHTYKKA FEGVLNNLER RHRETESEQV REELEKYMDV MPCPTCQGAR
     LKKEALFVRV GGENIQQVTA YSIQDALSFF DSLALSEKEE DIARRILKEI RERLNFLVNV
     GLDYLSLDRS SGTLSGGEGQ RIRLATQIGS SLVGVLYILD EPSIGLHQRD NGRLLSTLRH
     LRDIGNTVLV VEHDEETISE ADWVIDMGPG AGVHGGEVVA EGTPAEIMAN PHSLTGRYLS
     GALTIAIPKK RRKGSRFLSI EGANENNLKD VSVDLPLGVM TCITGVSGSG KSSLIIDTLY
     KTLNQRLYKS REKAGAVRAI HGMEVLDKVI NIDQSPIGRT PRSNPATYTG LFTEIREIFA
     QLPESKMRGY KPGRYSFNVK GGRCEACAGD GIIKIEMHFL PDVYVQCEVC KGARYNRETL
     EVRFKGRSIA EVLDMTVSQA LVFLEHIPRL KAKLQTLEEV GLGYIKLGQS ATTLSGGEAQ
     RVKLAKELSK RATGRTIYIL DEPTTGLHFA DIAKLLEVLH KLVDAGNSIV VIEHNLDVIK
     TADWIVDLGP EGGDRGGEVI AVGTPEQVSR VERSYTGQYL KKMLPHG
//
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