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Database: UniProt/TrEMBL
Entry: C6L245_PIG
LinkDB: C6L245_PIG
Original site: C6L245_PIG 
ID   C6L245_PIG              Unreviewed;       247 AA.
AC   C6L245;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   25-APR-2018, entry version 63.
DE   SubName: Full=Putative trypsinogen {ECO:0000313|EMBL:BAH86963.1};
GN   Name=try {ECO:0000313|EMBL:BAH86963.1};
GN   Synonyms=PRSS2 {ECO:0000313|Ensembl:ENSSSCP00000017461};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:BAH86963.1};
RN   [1] {ECO:0000313|EMBL:BAH86963.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19527749; DOI=10.1016/j.dci.2009.06.006;
RA   Eguchi-Ogawa T., Toki D., Uenishi H.;
RT   "Genomic structure of the whole D-J-C clusters and the upstream region
RT   coding V segments of the TRB locus in pig.";
RL   Dev. Comp. Immunol. 33:1111-1119(2009).
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000017461, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000017461};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000017461}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AEMK02000111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB476299; BAH86963.1; -; Genomic_DNA.
DR   EMBL; AB476300; BAH86994.1; -; Genomic_DNA.
DR   RefSeq; NP_001193367.1; NM_001206438.1.
DR   UniGene; Ssc.25371; -.
DR   STRING; 9823.ENSSSCP00000017461; -.
DR   MEROPS; S01.120; -.
DR   PeptideAtlas; C6L245; -.
DR   Ensembl; ENSSSCT00000017942; ENSSSCP00000017461; ENSSSCG00000016478.
DR   GeneID; 100525899; -.
DR   KEGG; ssc:100525899; -.
DR   CTD; 5645; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00760000118862; -.
DR   KO; K01312; -.
DR   OMA; SALPWIN; -.
DR   OrthoDB; EOG091G0DF7; -.
DR   TreeFam; TF331065; -.
DR   Reactome; R-SSC-1442490; Collagen degradation.
DR   Reactome; R-SSC-1592389; Activation of Matrix Metalloproteinases.
DR   Reactome; R-SSC-196741; Cobalamin (Cbl, vitamin B12) transport and metabolism.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   Reactome; R-SSC-6803157; Antimicrobial peptides.
DR   Proteomes; UP000008227; Chromosome 18.
DR   Bgee; ENSSSCG00000016478; -.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0007586; P:digestion; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:C6L245};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    247       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014086453.
FT   DOMAIN       24    244       Peptidase S1. {ECO:0000259|PROSITE:
FT                                PS50240}.
SQ   SEQUENCE   247 AA;  26178 MW;  D0EA90A301324BAC CRC64;
     MNPLLILACI GAAVAFPTDD DDKIVGGYTC AANSVPYQVS LNSGYHFCGG SLISDQWVVS
     AAHCYKSRIQ VRLGENNIDV LEGDEQFIDA AKIIRHPKYN SWTLDNDILL IKLSSPAVLN
     SRVSTLALPS ACAPAGTLCL ISGWGNTLSS GVNYPELLQC LDAPLLSQAE CEASYPGEIT
     SNMVCAGFLE GGKDSCQGDS GGPVACNGQL QGIVSWGYGC AQKNRPGVYT KVCNYVDWIQ
     QTIAANS
//
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