ID C6STF9_STRMN Unreviewed; 158 AA.
AC C6STF9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 01-MAY-2013, entry version 28.
DE RecName: Full=S-ribosylhomocysteine lyase;
DE EC=4.4.1.21;
DE AltName: Full=AI-2 synthesis protein;
DE AltName: Full=Autoinducer-2 production protein LuxS;
GN Name=luxS; OrderedLocusNames=SmuNN2025_0080;
OS Streptococcus mutans serotype c (strain NN2025).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=511691;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NN2025;
RX PubMed=19656368; DOI=10.1186/1471-2164-10-358;
RA Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A.,
RA Nakano K., Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M.,
RA Hamada S., Nakagawa I.;
RT "Comparative genomic analyses of Streptococcus mutans provide insights
RT into chromosomal shuffling and species-specific content.";
RL BMC Genomics 10:358-358(2009).
CC -!- FUNCTION: Involved in the synthesis of autoinducer 2 (AI-2) which
CC is secreted by bacteria and is used to communicate both the cell
CC density and the metabolic potential of the environment. The
CC regulation of gene expression in response to changes in cell
CC density is called quorum sensing. Catalyzes the transformation of
CC S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-
CC dihydroxy-2,3-pentadione (DPD) (By similarity).
CC -!- CATALYTIC ACTIVITY: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-
CC homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.
CC -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the LuxS family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AP010655; BAH87106.1; -; Genomic_DNA.
DR RefSeq; YP_003483998.1; NC_013928.1.
DR EnsemblBacteria; BAH87106; BAH87106; SmuNN2025_0080.
DR GeneID; 8835715; -.
DR KEGG; smc:SmuNN2025_0080; -.
DR PATRIC; 35311981; VBIStrMut11111_0078.
DR HOGENOM; HOG000040372; -.
DR KO; K07173; -.
DR OMA; FTINHNI; -.
DR ProtClustDB; PRK02260; -.
DR BioCyc; SMUT511691:GH9C-131-MONOMER; -.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043768; F:S-ribosylhomocysteine lyase activity; IEA:HAMAP.
DR GO; GO:0008152; P:metabolic process; IEA:GOC.
DR GO; GO:0009372; P:quorum sensing; IEA:HAMAP.
DR Gene3D; 3.30.1360.80; -; 1.
DR HAMAP; MF_00091; LuxS; 1; -.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR003815; S-ribosylhomocysteinase.
DR Pfam; PF02664; LuxS; 1.
DR PIRSF; PIRSF006160; AI2; 1.
DR PRINTS; PR01487; LUXSPROTEIN.
DR ProDom; PD013172; S-ribosylhomocysteinase; 1.
DR SUPFAM; SSF63411; Metalloenz_metal-bd; 1.
PE 3: Inferred from homology;
KW Autoinducer synthesis; Complete proteome; Iron; Lyase; Metal-binding;
KW Quorum sensing.
FT METAL 54 54 Iron (By similarity).
FT METAL 58 58 Iron (By similarity).
FT METAL 125 125 Iron (By similarity).
SQ SEQUENCE 158 AA; 17962 MW; 67309C470D3BF66A CRC64;
MARVESFELD HTKVRAPYVR KIDTQVGEKG DSISNFDIRL VQPNQSAIPS GGIHTIEHSL
ASLIRNRIDG VIDFSPFGCR TGFHLIIWGN HTSKEIALVI KESLKEMVSD EFRWENVPGI
SERQCGNYRD HSLFTAKEWG KQILRQGISS DPFLRKIV
//
