ID C6WB10_ACTMD Unreviewed; 954 AA.
AC C6WB10;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 01-MAY-2013, entry version 38.
DE RecName: Full=UvrABC system protein A;
DE Short=UvrA protein;
DE AltName: Full=Excinuclease ABC subunit A;
GN Name=uvrA; OrderedLocusNames=Amir_5483;
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS 3971).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Pseudonocardineae; Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971;
RX DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A.,
RA Glavina del Rio T., Nolan M., Lucas S., Tice H., Cheng J.-F.,
RA Chertkov O., Bruce D., Goodwin L., Pitluck S., Rohde M., Goeker M.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA Hauser L., Chang Y.-J., Jeffries C.C., Brettin T., Detter J.C.,
RA Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.-P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding
CC protein. A damage recognition complex composed of 2 UvrA and 2
CC UvrB subunits scans DNA for abnormalities. When the presence of a
CC lesion has been verified by UvrB, the UvrA molecules dissociate
CC (By similarity).
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA
CC family.
CC -!- SIMILARITY: Contains 1 ABC transporter domain.
CC -!- SIMILARITY: Contains 2 ABC transporter domains.
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DR EMBL; CP001630; ACU39301.1; -; Genomic_DNA.
DR RefSeq; YP_003103147.1; NC_013093.1.
DR STRING; 446462.Amir_5483; -.
DR EnsemblBacteria; ACU39301; ACU39301; Amir_5483.
DR GeneID; 8329689; -.
DR KEGG; ami:Amir_5483; -.
DR PATRIC; 20774064; VBIActMir80567_5635.
DR eggNOG; COG0178; -.
DR HOGENOM; HOG000050448; -.
DR KO; K03701; -.
DR OMA; INAIHRH; -.
DR ProtClustDB; PRK00349; -.
DR BioCyc; AMIR446462:GH7R-5543-MONOMER; -.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:HAMAP.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
DR GO; GO:0008270; F:zinc ion binding; IEA:HAMAP.
DR GO; GO:0006200; P:ATP catabolic process; IEA:GOC.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
DR GO; GO:0009432; P:SOS response; IEA:HAMAP.
DR GO; GO:0006810; P:transport; IEA:HAMAP.
DR Gene3D; 3.30.1490.20; -; 2.
DR HAMAP; MF_00205; UvrA; 1; -.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR004602; UvrA.
DR Pfam; PF00005; ABC_tran; 1.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW DNA repair; DNA-binding; Excision nuclease; Membrane; Metal-binding;
KW Nucleotide-binding; Repeat; SOS response; Transport; Zinc;
KW Zinc-finger.
FT DOMAIN 621 949 ABC transporter (By similarity).
FT NP_BIND 34 41 ATP (By similarity).
FT ZN_FING 259 287 C4-type (By similarity).
FT NP_BIND 653 660 ATP (By similarity).
FT ZN_FING 752 778 C4-type (By similarity).
SQ SEQUENCE 954 AA; 104496 MW; D6E6376C6E3A2176 CRC64;
MGVADRLVVR GAREHNLRGV DLDLPRDSLI VFTGLSGSGK SSLAFDTIFA EGQRRYVESL
SAYARQFLGQ MDKPDVDFIE GLSPAVSIDQ KSTSRNPRST VGTITEVYDY LRLLYARAGK
AHCPVCGEAI SKQTPQQIVD QVLAMEQGVK FQVLAPIVRG RKGEYVDLFA NLQTQGYSRV
KVDGQVHALT DVPKLKKQEK HEIAAVIDRL AVKTSAKQRL TDSVETALRL ADGLVELEFV
DLPENDPARV RRFSENLACP NSHPLAIEDL EPRSFSFNSP YGACPTCTGL GVRMEVDPEL
VVPDDELPLG EGAIAPWAGG QTADYFTRLL ESLSLAIGFR MDTPWRQLPA KVQKAVLHGV
DEQVNVRYRN RYGRERSYYA DFEGVIPFLE RRLEQTESES MKEKYEGYMR EVPCPSCKGT
RLKPEILAVT LDHGALGPKS IAEVCAMSVG ECSDFLDGLK LGQRESMIAG AVLKEIQARL
RFLLDVGLNY LSLGRASGTL SGGEAQRIRL ATQIGSGLVG VLYVLDEPSI GLHQRDNHRL
IETLTRLRDL GNTLIVVEHD EDTVRASDWV VDIGPGAGEH GGHVVHSGPY KALLRNKESV
TGAYLSGRKQ IPMPELRRPI DKKRQLTVVG AREHNLRGID VSFPLGCLVS VTGVSGSGKS
TLVNDILATV LANKLNGARQ VPGRHTRVKG LEHVDKLVQV DQSPIGRTPR SNPATYTGVF
DHIRKLFAAT TEAKVRGYQP GRFSFNVKGG RCEACAGDGT LKIEMNFLPD VYVPCEVCKG
ARYNRETLEV HYKGKTISEV LDMPIEEAAD FFEPINAIHR HLRTLVDVGL GYVRLGQPAT
TLSGGEAQRV KLGAELQKRS TGKTVYVLDE PTTGLHFEDI RKLLLVINGL VDKGNTVIVI
EHNLDVIKTS DWLVDMGPEG GSGGGIVVAE GTPEQVADVP ESHTGKFLTE VLKG
//
