ID C6X4W8_FLAB3 Unreviewed; 635 AA.
AC C6X4W8;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN OrderedLocusNames=FIC_01006 {ECO:0000313|EMBL:ACU07456.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU07456.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU07456.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU07456.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
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DR EMBL; CP001673; ACU07456.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X4W8; -.
DR STRING; 531844.FIC_01006; -.
DR KEGG; fba:FIC_01006; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_6_10; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACU07456.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001512}.
FT DOMAIN 12..68
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 70..462
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 519..598
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 635 AA; 72104 MW; D98C36886450CB42 CRC64;
MKNYFIDDLP DYFKQYKKSI KNPKKFWDKV ADENFVWYQR WSKVVEYDMQ EAKIKWFKNA
KLNITKNCID RHLNTRGDKT AIIWEPNDPK EEAQHISYSE LRDRVCKMAN VLRDMGIEKG
DRVCIYLPMI PELAVTMLAC ARLGAVHSVI FAGFSASAVT SRVNDCEAKL IICSDGSYRG
HKAIDLKGII DEAVESCPTV EKVLVVKRTG GDVKMKDGRD FWLEPLYEKA ASDFISVIMD
AEDPLFILYT SGSTGKPKGM LHTTAGYMVY TAYTFKNVFN YQENDIYWCT ADIGWITGHS
YILYGPLANG ATTVIFEGVP TYPEPDRFWE VIEKHKVTQF YTAPTAIRSL AKESYEWVEK
HDLSSLRVIG SVGEPINDEA WHWYNDHVGK KKCPIVDTWW QTETGGIMIS PIPFVTPTKP
TYATLPLPGI QPVLMDDKRN EITGNQVDGN LCIRFPWPGI ARTIWGDHQR YKETYFTAFP
GKYFTGDGAL RDEVGYYRIT GRVDDVIIVS GHNLGTAPIE DSINQHPAVA ESAIVGYPHD
IKGSALYGYV ILKDVGESRD RENLRKEINQ VISDTVGPIA KLDKIQFVSA LPKTRSGKIM
RRILRKIAEG DFANFGDIST LLNPEIVEEI KEERI
//
