ID C6X9S4_METSD Unreviewed; 180 AA.
AC C6X9S4;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 29-MAY-2013, entry version 30.
DE RecName: Full=Peptide methionine sulfoxide reductase MsrA;
DE Short=Protein-methionine-S-oxide reductase;
DE EC=1.8.4.11;
DE AltName: Full=Peptide-methionine (S)-S-oxide reductase;
GN Name=msrA; OrderedLocusNames=Msip34_0646;
OS Methylovorus sp. (strain SIP3-4) (Methylotenera sp. (strain SIP3-4)).
OC Bacteria; Proteobacteria; Betaproteobacteria; Methylophilales;
OC Methylophilaceae; Methylovorus.
OX NCBI_TaxID=582744;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SIP3-4;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Clum A., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M.,
RA Chistoserdova L.;
RT "Complete sequence of chromosome of Methylovorus sp. SIP3-4.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has an important function as a repair enzyme for
CC proteins that have been inactivated by oxidation. Catalyzes the
CC reversible oxidation-reduction of methionine sulfoxide in proteins
CC to methionine (By similarity).
CC -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC L-methionine (S)-S-oxide + thioredoxin.
CC -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
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DR EMBL; CP001674; ACT49894.1; -; Genomic_DNA.
DR RefSeq; YP_003050421.1; NC_012969.1.
DR ProteinModelPortal; C6X9S4; -.
DR STRING; 582744.Msip34_0646; -.
DR EnsemblBacteria; ACT49894; ACT49894; Msip34_0646.
DR GeneID; 8172540; -.
DR KEGG; mei:Msip34_0646; -.
DR PATRIC; 22616298; VBIMetSp110381_0653.
DR eggNOG; COG0225; -.
DR KO; K07304; -.
DR OMA; YCLAVIP; -.
DR ProtClustDB; CLSK2529646; -.
DR BioCyc; MGLU582744:GHXQ-666-MONOMER; -.
DR GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:HAMAP.
DR GO; GO:0006464; P:cellular protein modification process; IEA:HAMAP.
DR Gene3D; 3.30.1060.10; -; 1.
DR HAMAP; MF_01401; MsrA; 1; -.
DR InterPro; IPR002569; Met_Sox_Rdtase_MsrA.
DR Pfam; PF01625; PMSR; 1.
DR SUPFAM; SSF55068; MsrA; 1.
DR TIGRFAMs; TIGR00401; msrA; 1.
PE 3: Inferred from homology;
KW Complete proteome; Oxidoreductase.
FT ACT_SITE 14 14 By similarity.
SQ SEQUENCE 180 AA; 20281 MW; 2960C96C0DA11CCB CRC64;
MVKELDVAVL AGGCFWCLEP VFSQLDGVEK VVSGYTGGHT LQPDYKQVCR GDTGHAEAIR
ISFDPARISF YELLEIFFLS HDPTTPNRQG NDIGTQYRSA IFCQNAAQRS TAEQMIAELN
QLHVFASPIV TEVNDAAVFY AAEDYHQQYY EQHQEQPYCM LVAAPKVAKI RAKFPEKIRN
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