ID   C7CKN5_METED            Unreviewed;       244 AA.
AC   C7CKN5;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   01-MAY-2013, entry version 24.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=METDI5192;
OS   Methylobacterium extorquens (strain DSM 5838 / DM4) (Methylobacterium
OS   dichloromethanicum (strain DM4)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=661410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5838 / DM4;
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.C., Bringel F., Lajus A.,
RA   Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C.,
RA   Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S.,
RA   Muller E., Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G.,
RA   Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z.,
RA   Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J.,
RA   Medigue C., Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to
RT   investigate microbial metabolism of C1 compounds from natural and
RT   industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR   EMBL; FP103042; CAX26805.1; -; Genomic_DNA.
DR   RefSeq; YP_003070617.1; NC_012988.1.
DR   STRING; 661410.METDI5192; -.
DR   EnsemblBacteria; CAX26805; CAX26805; METDI5192.
DR   GeneID; 8195570; -.
DR   KEGG; mdi:METDI5192; -.
DR   PATRIC; 22528843; VBIMetExt143287_4930.
DR   eggNOG; COG0125; -.
DR   HOGENOM; HOG000229078; -.
DR   KO; K00943; -.
DR   OMA; ITLEGPE; -.
DR   ProtClustDB; CLSK2332037; -.
DR   BioCyc; MEXT661410:GJA1-5104-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; PTHR10344; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND      15     22       ATP (By similarity).
SQ   SEQUENCE   244 AA;  26169 MW;  B57F2583EAE4BA94 CRC64;
     MSSDAPRGVF ITFEGGEGAG KSTQIARLAE TLRRVSGREV VTTREPGGTE RAEALRAALL
     RGVAKPYGPF AEALMFAAAR IDHIENLIRP ALDRGAIVLC DRFSDSTRAY QGAAGGLDPA
     LIDSLERVTL EDLRPDLTLI LDLPPEAGLA RARRRGAGEP ADRFEAEGMR FHERLRAAFR
     SIAEAEPERC RVIDADLGPD AVETAIAAAI AARWPDLLPA TGEGQGQEGK VRESKDREGH
     GHAA
//