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Database: UniProt/TrEMBL
Entry: C7NUJ1_HALUD
LinkDB: C7NUJ1_HALUD
Original site: C7NUJ1_HALUD 
ID   C7NUJ1_HALUD            Unreviewed;       489 AA.
AC   C7NUJ1;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   11-JUN-2014, entry version 28.
DE   RecName: Full=tRNA-guanine(15) transglycosylase;
DE            EC=2.4.2.48;
DE   AltName: Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase;
DE   AltName: Full=Archaeal tRNA-guanine transglycosylase;
GN   Name=tgtA; OrderedLocusNames=Huta_2181;
OS   Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2).
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halorhabdus.
OX   NCBI_TaxID=519442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12940 / JCM 11049 / AX-2;
RX   DOI=10.4056/sigs.31864;
RA   Anderson I., Tindall B.J., Pomrenke H., Goker M., Lapidus A.,
RA   Nolan M., Copeland A., Glavina Del Rio T., Chen F., Tice H.,
RA   Cheng J.F., Lucas S., Chertkov O., Bruce D., Brettin T., Detter J.C.,
RA   Han C., Goodwin L., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Pitluck S., Pati A., Mavromatis K., Ivanova N., Ovchinnikova G.,
RA   Chen A., Palaniappan K., Chain P., Rohde M., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Halorhabdus utahensis type strain (AX-
RT   2).";
RL   Stand. Genomic Sci. 1:218-225(2009).
CC   -!- FUNCTION: Exchanges the guanine residue with 7-cyano-7-
CC       deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-
CC       loop) of archaeal tRNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: Guanine(15) in tRNA + 7-cyano-7-carbaguanine =
CC       7-cyano-7-carbaguanine(15) in tRNA + guanine.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: tRNA modification; archaeosine-tRNA biosynthesis.
CC   -!- SIMILARITY: Belongs to the archaeosine tRNA-ribosyltransferase
CC       family.
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DR   EMBL; CP001687; ACV12348.1; -; Genomic_DNA.
DR   RefSeq; YP_003131081.1; NC_013158.1.
DR   STRING; 519442.Huta_2181; -.
DR   EnsemblBacteria; ACV12348; ACV12348; Huta_2181.
DR   GeneID; 8384475; -.
DR   KEGG; hut:Huta_2181; -.
DR   eggNOG; COG0343; -.
DR   HOGENOM; HOG000231009; -.
DR   KO; K00773; -.
DR   OMA; RCRSHPR; -.
DR   BioCyc; HUTA519442:GH3V-2216-MONOMER; -.
DR   UniPathway; UPA00393; -.
DR   GO; GO:0008479; F:queuine tRNA-ribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.105; -; 1.
DR   HAMAP; MF_01634; TgtA_arch; 1.
DR   InterPro; IPR004804; TgtA.
DR   InterPro; IPR002616; tRNA_ribo_trans-like.
DR   PANTHER; PTHR11962; PTHR11962; 1.
DR   Pfam; PF01702; TGT; 1.
DR   SUPFAM; SSF51713; SSF51713; 1.
DR   TIGRFAMs; TIGR00432; arcsn_tRNA_tgt; 1.
DR   TIGRFAMs; TIGR00449; tgt_general; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycosyltransferase; Metal-binding; Transferase;
KW   tRNA processing; Zinc.
FT   ACT_SITE     92     92       Nucleophile (By similarity){EA2}.
FT   METAL       278    278       Zinc (By similarity){EA2}.
FT   METAL       280    280       Zinc (By similarity){EA2}.
FT   METAL       283    283       Zinc (By similarity){EA2}.
SQ   SEQUENCE   489 AA;  53566 MW;  11E82DDA4BF5F438 CRC64;
     MRDHFELQAY DAMGRLGELT VPRADVTVET PALLPVINPH HETIDPGRLA EFGAEILITN
     SYVIYGSDEV REPALEDGLH DLLDFDGAIM TDSGSFQLAE YGEIDVNTTE ILEFQREIGS
     DIATPVDIPT PPDADREQVG REMETTQARL ETAADFDAGE MLLNAPVQGA TYPDLREQAA
     RDAYATGLDV FPIGAVVPLL NDYRYGEMVD AVAGAKRGLG EDAPVHLFGA GHPMMFALAV
     AAGCDLFDSA AYALYARDGR YLTVRGTEHL DELEHFPCEC PVCSARTPAE LRDRPTHERT
     KLLAEHNLHV SFGEMRRIKQ AIRQGNLLEL VETRARAHPT MLDGYRALLD HAEQLERTDP
     ASKDAFFYLS GESAARPEVR RHHDRLARLS PPADLLLATD PDAHAGADAD VWAVEPPFGP
     VPRGLDQTYP LTAELPDRLD DRAYRAAARG VNRLAETSDA AITLVDDGWP ASALDLLAEG
     VDIDTTVEE
//
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