ID C8TTX5_ECO26 Unreviewed; 361 AA.
AC C8TTX5;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 01-MAY-2013, entry version 28.
DE RecName: Full=dTDP-glucose 4,6-dehydratase;
DE EC=4.2.1.46;
GN Name=rmlB; OrderedLocusNames=ECO26_2952;
OS Escherichia coli O26:H11 (strain 11368 / EHEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=573235;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11368 / EHEC;
RX PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA Hayashi T.;
RT "Comparative genomics reveal the mechanism of the parallel evolution
RT of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC -!- CATALYTIC ACTIVITY: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-
CC alpha-D-glucose + H(2)O.
CC -!- COFACTOR: NAD (By similarity).
CC -!- SIMILARITY: Belongs to the sugar epimerase family. dTDP-glucose
CC dehydratase subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AP010953; BAI26175.1; -; Genomic_DNA.
DR RefSeq; YP_003229915.1; NC_013361.1.
DR ProteinModelPortal; C8TTX5; -.
DR SMR; C8TTX5; 1-352.
DR STRING; 573235.ECO26_2952; -.
DR EnsemblBacteria; BAI26175; BAI26175; ECO26_2952.
DR GeneID; 8482389; -.
DR KEGG; eoj:ECO26_2952; -.
DR PATRIC; 18401556; VBIEscCol24965_3014.
DR eggNOG; COG1088; -.
DR HOGENOM; HOG000168006; -.
DR KO; K01710; -.
DR ProtClustDB; PRK10084; -.
DR GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR10366:SF41; PTHR10366:SF41; 1.
DR Pfam; PF01370; Epimerase; 1.
DR TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE 3: Inferred from homology;
KW Complete proteome; Lyase.
SQ SEQUENCE 361 AA; 40533 MW; D5DBE79A268F0550 CRC64;
MKILVTGGAG FIGSAVVRHI INNTQDSVVN VDKLTYAGNL ESLADVSDSE RYVFEHADIC
DAAAMARIFA QHQPDAVMHL AAESHVDRSI TGPAAFIETN IVGTYVLLEA ARNYWSALDS
DKKNSFRFHH ISTDEVYGDL PHPDEVNNTE ELPLFTETTA YAPSSPYSAS KASSDHLVRA
WKRTYGLPTI VTNCSNNYGP YHFPEKLIPL VILNALEGKA LPIYGKGDQI RDWLYVEDHA
RALYTVVTEG KAGETYNIGG HNEKKNIDVV LTICDLLDEI VPKEQSYREQ ITYVADRPGH
DRRYAIDAEK ISRELGWKPQ ETFESGIRKT VEWYLSNTKW VENVKSGAYQ SWIAQNYEGR
Q
//
