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Database: UniProt/TrEMBL
Entry: C9XKU8_CLODC
LinkDB: C9XKU8_CLODC
Original site: C9XKU8_CLODC 
ID   C9XKU8_CLODC            Unreviewed;      2710 AA.
AC   C9XKU8;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   19-FEB-2014, entry version 24.
DE   SubName: Full=Toxin A;
GN   Name=tcdA; OrderedLocusNames=CD196_0602;
OS   Clostridium difficile (strain CD196).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Peptostreptococcaceae.
OX   NCBI_TaxID=645462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD196;
RX   PubMed=19781061; DOI=10.1186/gb-2009-10-9-r102;
RA   Stabler R.A., He M., Dawson L., Martin M., Valiente E., Corton C.,
RA   Lawley T.D., Sebaihia M., Quail M.A., Rose G., Gerding D.N.,
RA   Gibert M., Popoff M.R., Parkhill J., Dougan G., Wren B.W.;
RT   "Comparative genome and phenotypic analysis of Clostridium difficile
RT   027 strains provides insight into the evolution of a hypervirulent
RT   bacterium.";
RL   Genome Biol. 10:R102.1-R102.15(2009).
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DR   EMBL; FN538970; CBA61156.1; -; Genomic_DNA.
DR   RefSeq; YP_003213641.1; NC_013315.1.
DR   STRING; 645462.CD196_0602; -.
DR   EnsemblBacteria; CBA61156; CBA61156; CD196_0602.
DR   GeneID; 8466712; -.
DR   KEGG; cdc:CD196_0602; -.
DR   PATRIC; 19447424; VBICloDif125228_0635.
DR   eggNOG; COG5263; -.
DR   HOGENOM; HOG000122990; -.
DR   KO; K11063; -.
DR   OMA; TSINGKH; -.
DR   OrthoDB; EOG6XHC05; -.
DR   BioCyc; CDIF645462:GJED-686-MONOMER; -.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:GOC.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR   InterPro; IPR020974; Pept_C80_RTX.
DR   InterPro; IPR024770; TcdA/TcdB_cat.
DR   InterPro; IPR024772; TcdA/TcdB_N.
DR   InterPro; IPR024769; TcdA/TcdB_pore_forming.
DR   Pfam; PF01473; CW_binding_1; 14.
DR   Pfam; PF11713; Peptidase_C80; 1.
DR   Pfam; PF12919; TcdA_TcdB; 1.
DR   Pfam; PF12920; TcdA_TcdB_pore; 1.
DR   Pfam; PF12918; TcdB_N; 1.
DR   PROSITE; PS51170; CW; 33.
PE   4: Predicted;
KW   Complete proteome.
SQ   SEQUENCE   2710 AA;  308311 MW;  8A6BCDAAD2949FE9 CRC64;
     MSLISKEELI KLAYSIRPRE NEYKTILTNL DEYNKLTTNN NENKYLQLKK LNESIDVFMN
     KYKNSSRNRA LSNLKKDILK EVILIKNSNT SPVEKNLHFV WIGGEVSDIA LEYIKQWADI
     NAEYNIKLWY DSEAFLVNTL KKAIVESSTT EALQLLEEEI QNPQFDNMKF YKKRMEFIYD
     RQKRFINYYK SQINKPTVPT IDDIIKSHLV SEYNRDETLL ESYRTNSLRK INSNHGIDIR
     ANSLFTEQEL LNIYSQELLN RGNLAAASDI VRLLALKNFG GVYLDVDMLP GIHSDLFKTI
     PRPSSIGLDR WEMIKLEAIM KYKKYINNYT SENFDKLDQQ LKDNFKLIIE SKSEKSEIFS
     KLENLNVSDL EIKIAFALGS VINQALISKQ GSYLTNLVIE QVKNRYQFLN QHLNPAIESD
     NNFTDTTKIF HDSLFNSATA ENSMFLTKIA PYLQVGFMPE ARSTISLSGP GAYASAYYDF
     INLQENTIEK TLKASDLIEF KFPENNLSQL TEQEINSLWS FDQASAKYQF EKYVRDYTGG
     SLSEDNGVDF NKNTALDKNY LLNNKIPSNN VEEAGSKNYV HYIIQLQGDD ISYEATCNLF
     SKNPKNSIII QRNMNESAKS YFLSDDGESI LELNKYRIPE RLKNKEKVKV TFIGHGKDEF
     NTSEFARLSV DSLSNEISSF LDTIKLDISP KNVEVNLLGC NMFSYDFNVE ETYPGKLLLS
     IMDKITSTLP DVNKDSITIG ANQYEVRINS EGRKELLAHS GKWINKEEAI MSDLSSKEYI
     FFDSIDNKLK AKSKNIPGLA SISEDIKTLL LDASVSPDTK FILNNLKLNI ESSIGDYIYY
     EKLEPVKNII HNSIDDLIDE FNLLENVSDE LYELKKLNNL DEKYLISFED ISKNNSTYSV
     RFINKSNGES VYVETEKEIF SKYSEHITKE ISTIKNSIIT DVNGNLLDNI QLDHTSQVNT
     LNAAFFIQSL IDYSSNKDVL NDLSTSVKVQ LYAQLFSTGL NTIYDSIQLV NLISNAVNDT
     INVLPTITEG IPIVSTILDG INLGAAIKEL LDEHDPLLKK ELEAKVGVLA INMSLSIAAT
     VASIVGIGAE VTIFLLPIAG ISAGIPSLVN NELILHDKAT SVVNYFNHLS ESKEYGPLKT
     EDDKILVPID DLVISEIDFN NNSIKLGTCN ILAMEGGSGH TVTGNIDHFF SSPYISSHIP
     SLSVYSAIGI KTENLDFSKK IMMLPNAPSR VFWWETGAVP GLRSLENNGT KLLDSIRDLY
     PGKFYWRFYA FFDYAITTLK PVYEDTNTKI KLDKDTRNFI MPTITTDEIR NKLSYSFDGA
     GGTYSLLLSS YPISMNINLS KDDLWIFNID NEVREISIEN GTIKKGNLIE DVLSKIDINK
     NKLIIGNQTI DFSGDIDNKD RYIFLTCELD DKISLIIEIN LVAKSYSLLL SGDKNYLISN
     LSNTIEKINT LGLDSKNIAY NYTDESNNKY FGAISKTSQK SIIHYKKDSK NILEFYNGST
     LEFNSKDFIA EDINVFMKDD INTITGKYYV DNNTDKSIDF SISLVSKNQV KVNGLYLNES
     VYSSYLDFVK NSDGHHNTSN FMNLFLNNIS FWKLFGFENI NFVIDKYFTL VGKTNLGYVE
     FICDNNKNID IYFGEWKTSS SKSTIFSGNG RNVVVEPIYN PDTGEDISTS LDFSYEPLYG
     IDRYINKVLI APDLYTSLIN INTNYYSNEY YPEIIVLNPN TFHKKVNINL DSSSFEYKWS
     TEGSDFILVR YLEESNKKIL QKIRIKGILS NTQSFNKMSI DFKDIKKLSL GYIMSNFKSF
     NSENELDRDH LGFKIIDNKT YYYDEDSKLV KGLININNSL FYFDPIESNL VTGWQTINGK
     KYYFDINTGA ASTSYKIING KHFYFNNNGV MQLGVFKGPD GFEYFAPANT QNNNIEGQAI
     VYQSKFLTLN GKKYYFDNDS KAVTGWRIIN NEKYYFNPNN AIAAVGLQVI DNNKYYFNPD
     TAIISKGWQT VNGSRYYFDT DTAIAFNGYK TIDGKHFYFD SDCVVKIGVF SGSNGFEYFA
     PANTYNNNIE GQAIVYQSKF LTLNGKKYYF DNNSKAVTGW QTIDSKKYYF NTNTAEAATG
     WQTIDGKKYY FNTNTAEAAT GWQTIDGKKY YFNTNTSIAS TGYTIINGKY FYFNTDGIMQ
     IGVFKVPNGF EYFAPANTHN NNIEGQAILY QNKFLTLNGK KYYFGSDSKA ITGWQTIDGK
     KYYFNPNNAI AATHLCTINN DKYYFSYDGI LQNGYITIER NNFYFDANNE SKMVTGVFKG
     PNGFEYFAPA NTHNNNIEGQ AIVYQNKFLT LNGKKYYFDN DSKAVTGWQT IDSKKYYFNL
     NTAVAVTGWQ TIDGEKYYFN LNTAEAATGW QTIDGKRYYF NTNTYIASTG YTIINGKHFY
     FNTDGIMQIG VFKGPDGFEY FAPANTHNNN IEGQAILYQN KFLTLNGKKY YFGSDSKAVT
     GLRTIDGKKY YFNTNTAVAV TGWQTINGKK YYFNTNTYIA STGYTIISGK HFYFNTDGIM
     QIGVFKGPDG FEYFAPANTD ANNIEGQAIR YQNRFLYLHD NIYYFGNDSK AATGWATIDG
     NRYYFEPNTA MGANGYKTID NKNFYFRNGL PQIGVFKGPN GFEYFAPANT DANNIDGQAI
     RYQNRFLHLL GKIYYFGNNS KAVTGWQTIN SKVYYFMPDT AMAAAGGLFE IDGVIYFFGV
     DGVKAPGIYG
//
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