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Database: UniProt/TrEMBL
Entry: D1AP39_SEBTE
LinkDB: D1AP39_SEBTE
Original site: D1AP39_SEBTE 
ID   D1AP39_SEBTE            Unreviewed;       318 AA.
AC   D1AP39;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   11-JUN-2014, entry version 35.
DE   RecName: Full=Ribose-phosphate pyrophosphokinase;
DE            Short=RPPK;
DE            EC=2.7.6.1;
DE   AltName: Full=Phosphoribosyl pyrophosphate synthase;
GN   Name=prs; OrderedLocusNames=Sterm_0640;
OS   Sebaldella termitidis (strain ATCC 33386 / NCTC 11300).
OC   Bacteria; Fusobacteria; Fusobacteriales; Leptotrichiaceae; Sebaldella.
OX   NCBI_TaxID=526218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33386 / NCTC 11300;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Sims D., Meincke L., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT   "The complete chromosome of Sebaldella termitidis ATCC 33386.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + D-ribose 5-phosphate = AMP + 5-phospho-
CC       alpha-D-ribose 1-diphosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-
CC       ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-
CC       diphosphate from D-ribose 5-phosphate (route I): step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase
CC       family.
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DR   EMBL; CP001739; ACZ07513.1; -; Genomic_DNA.
DR   RefSeq; YP_003307444.1; NC_013517.1.
DR   ProteinModelPortal; D1AP39; -.
DR   EnsemblBacteria; ACZ07513; ACZ07513; Sterm_0640.
DR   GeneID; 8596124; -.
DR   KEGG; str:Sterm_0640; -.
DR   PATRIC; 32405212; VBISebTer81212_0661.
DR   HOGENOM; HOG000210449; -.
DR   KO; K00948; -.
DR   OMA; VNEHLME; -.
DR   OrthoDB; EOG6Z99XQ; -.
DR   BioCyc; STER526218:GHLD-647-MONOMER; -.
DR   UniPathway; UPA00087; UER00172.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   HAMAP; MF_00583_B; RibP_PPkinase_B; 1.
DR   InterPro; IPR000842; PRib_PP_synth_CS.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01251; ribP_PPkin; 1.
DR   PROSITE; PS00114; PRPP_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium;
KW   Metal-binding; Nucleotide biosynthesis; Nucleotide-binding;
KW   Transferase.
FT   REGION      214    227       5-phosphoribose 1-diphosphate binding (By
FT                                similarity).
FT   METAL       129    129       Magnesium (By similarity){EA2}.
FT   METAL       131    131       Magnesium (By similarity){EA2}.
FT   METAL       140    140       Magnesium (By similarity){EA2}.
FT   METAL       144    144       Magnesium (By similarity){EA2}.
SQ   SEQUENCE   318 AA;  34890 MW;  34C1739032C98909 CRC64;
     MEKDFQIYAG SSSKALARQI AQKLGVELGS VDLIKFADGE TFAKVNQSVR GCMVFIVQST
     SKPVNESIME LLIFMDSLKR ASAAEIIPVI PYYGYARQDR KASPREPITS KLIADILTVA
     GASRVVTMDL HARQIQGFFD IPVDHMEALP ILAKYFIKNE LVGDDIVVVS PDVGGVKRAR
     SLAKWLHAPL AIIDKRRAKA NVSEVMNIIG DVAGKKAILI DDMIDTAGTI CNAAYALKEK
     GATEVFACAT HAILSDPAVE RLKAAPFNKV IVTDTIELPD NKRFENLEIL STDTMFSETI
     KRIVNDQAIS DLFELPHE
//
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