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Database: UniProt/TrEMBL
Entry: D1BZX3_XYLCX
LinkDB: D1BZX3_XYLCX
Original site: D1BZX3_XYLCX 
ID   D1BZX3_XYLCX            Unreviewed;       739 AA.
AC   D1BZX3;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   07-JUN-2017, entry version 55.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ACZ32101.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ACZ32101.1};
GN   OrderedLocusNames=Xcel_3100 {ECO:0000313|EMBL:ACZ32101.1};
OS   Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990
OS   / XIL07).
OC   Bacteria; Actinobacteria; Micrococcales; Promicromonosporaceae;
OC   Xylanimonas.
OX   NCBI_TaxID=446471 {ECO:0000313|EMBL:ACZ32101.1, ECO:0000313|Proteomes:UP000002255};
RN   [1] {ECO:0000313|Proteomes:UP000002255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15894 / CECT 5975 / LMG 20990 / XIL07
RC   {ECO:0000313|Proteomes:UP000002255};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Foster B., Clum A., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.F., Hugenholtz P., Woyke T., Wu D., Gehrich-Schroeter G.,
RA   Schneider S., Pukall S.R., Klenk H.P., Eisen J.A.;
RT   "The complete chromosome of Xylanimonas cellulosilytica DSM 15894.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACZ32101.1, ECO:0000313|Proteomes:UP000002255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15894 / CECT 5975 / LMG 20990 / XIL07
RC   {ECO:0000313|Proteomes:UP000002255};
RX   PubMed=21304672; DOI=10.4056/sigs.571102;
RA   Foster B., Pukall R., Abt B., Nolan M., Glavina Del Rio T., Chen F.,
RA   Lucas S., Tice H., Pitluck S., Cheng J.-F., Chertkov O., Brettin T.,
RA   Han C., Detter J.C., Bruce D., Goodwin L., Ivanova N., Mavromatis K.,
RA   Pati A., Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Chang Y.-J., Jeffries C.D., Chain P., Rohde M., Goeker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.-P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Xylanimonas cellulosilytica type strain
RT   (XIL07).";
RL   Stand. Genomic Sci. 2:1-8(2010).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP001821; ACZ32101.1; -; Genomic_DNA.
DR   RefSeq; WP_012879843.1; NC_013530.1.
DR   ProteinModelPortal; D1BZX3; -.
DR   STRING; 446471.Xcel_3100; -.
DR   EnsemblBacteria; ACZ32101; ACZ32101; Xcel_3100.
DR   KEGG; xce:Xcel_3100; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; XCEL446471:GHA2-3121-MONOMER; -.
DR   Proteomes; UP000002255; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002255};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ACZ32101.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002255}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       349    349       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     546    546       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        256    256       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        419    419       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  78457 MW;  F2A33A247406E99B CRC64;
     MAGPSTIIYT HTDEAPLLAT YSFLPIVQAF AGQAGVALET RDISVAARIL ALFPERLTEE
     QRVPDALAEL GRLADAPEAN IIKLPNVSAS VPQLKAAIAE LQAQGFDVPD YPEAPATDEE
     REIRARYDRV KGSAVNPVLR QGNSDRRAPA SVKAYAKAHP HRMGAWSPSS KTNVATMTEG
     DFFHNEKSVV IPADDTLTIR LVAADGSVSV LKDGLKVLAG EVVDGTFMSA RALRAFLAAQ
     VERAQADGVL FSAHLKATMM KVSDPIIFGH VVQAFLPAVF EQFGDSLRAA GVSANDGLGA
     LLAAASSLPD GEAIRQAVAE GLAAGPALAM VNSDKGITNL HVPSDVIIDA SMPAMIRGGG
     KMWGPDGAEH DTLAVIPDSS YAGVYQAAID DCRAHGALDP AAIGTVPNVG LMAQAAEEYG
     SHDKTFEIPV DGVVEVVASS GDVLFSHDVE AGDIWRACQT KDAPIRDWVA LAVRRARLSN
     TPAVFWLDAQ RAHDANLIEK LEQYLPEHDT EGLEIHVMAP AEATAFSFAR LRAGLDTISV
     TGNVLRDYNT DLFPILEVGT SAKMLSVVPL MNGGGLFETG AGGSAPKHVQ QLVEENYLRW
     DSLGEFFALA ASFEHLAQTT DNARAQLLAD TLDRATGTFL DEDRSPGRKL GTIDNRGSHF
     YLALYWAQEL AAQTTDPELA AAFAPLAAAL AENEQTIVDE LIAVQGKPAD IGGYYRPDAT
     LTSAVMRPSA TFNKALAAL
//
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