ID D1CAS9_SPHTD Unreviewed; 552 AA.
AC D1CAS9;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACZ40922.1};
GN OrderedLocusNames=Sthe_3523 {ECO:0000313|EMBL:ACZ40922.1};
OS Sphaerobacter thermophilus (strain DSM 20745 / S 6022).
OC Bacteria; Thermomicrobiota; Thermomicrobia; Sphaerobacterales;
OC Sphaerobacterineae; Sphaerobacteraceae; Sphaerobacter.
OX NCBI_TaxID=479434 {ECO:0000313|EMBL:ACZ40922.1, ECO:0000313|Proteomes:UP000002027};
RN [1] {ECO:0000313|Proteomes:UP000002027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49802 / DSM 20745 / S 6022
RC {ECO:0000313|Proteomes:UP000002027};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., LaButti K.M., Clum A., Sun H.I., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F.,
RA Hugenholtz P., Woyke T., Wu D., Steenblock K., Schneider S., Pukall R.,
RA Goeker M., Klenk H.P., Eisen J.A.;
RT "The complete chromosome 2 of Sphaerobacter thermophilus DSM 20745.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACZ40922.1, ECO:0000313|Proteomes:UP000002027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49802 / DSM 20745 / S 6022
RC {ECO:0000313|Proteomes:UP000002027};
RX PubMed=21304676;
RA Spring S., Nolan M., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA Cheng J.F., Lucas S., Land M., Chen F., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Hauser L., Chang Y.J., Jeffries C.D., Munk C., Kiss H., Chain P., Han C.,
RA Brettin T., Detter J.C., Schuler E., Goker M., Rohde M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Desulfohalobium retbaense type strain
RT (HR(100)).";
RL Stand. Genomic Sci. 2:38-48(2010).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP001824; ACZ40922.1; -; Genomic_DNA.
DR RefSeq; WP_012873957.1; NC_013524.1.
DR AlphaFoldDB; D1CAS9; -.
DR STRING; 479434.Sthe_3523; -.
DR KEGG; sti:Sthe_3523; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_59_10_0; -.
DR InParanoid; D1CAS9; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000002027; Chromosome 2.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACZ40922.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002027}.
FT DOMAIN 48..406
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 456..534
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 552 AA; 60808 MW; 75FE8146F3B4A6D8 CRC64;
MASAPSVEPN MRDYEETRRT FRWDVPEYYN FAVDTIGMWA ADPARPGMVH VDHEGRERTI
TFAEFAQRSD RLASALRQHG IGPGDRVLVV LPRVPEWWEA ILGIMKVGAI SLPGTTLLRP
RDLEYRINAS GAKGIITDPE VAARVDEVAG SCPTLTVPIV VGGERDGWIS YDAALAEAPA
DFEPVRTRSD DPCMLYFTSG TTAHPKMVLH THASYPIGHV VTGRFWLDLR PGDLHWNLSD
NGWAKAAWSS LFGPWSVGAT LFIHDARGRF DAGQTLATLE RYPITSFCAA PTIYRMLVLE
DLAKFKPAAL RSCVGAGEPL NPEVIETWRE ATGMTIRDGY GQTESAVLVA NFPSVPVRVG
AMGKPTPGFE VAIIDDEGRE LPPGEEGHIG VRIKPGRPVG LFHGYYGDEA LTNEVFAGEW
YYTGDRARRD EDSYFWFVGR ADDVILSAGY RISPFEVESA LLEHPAVAEA AVVGSPDPIR
GQIVKAFVVL VPGTETSPTL AQEIQDFTRK VTAPYKYPRE IEFVAELPKT ISGKIRRVEL
REREVARKGG GS
//
