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Database: UniProt/TrEMBL
Entry: D2H2R3_AILME
LinkDB: D2H2R3_AILME
Original site: D2H2R3_AILME 
ID   D2H2R3_AILME            Unreviewed;       911 AA.
AC   D2H2R3;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   25-OCT-2017, entry version 51.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
DE   Flags: Fragment;
GN   ORFNames=PANDA_003934 {ECO:0000313|EMBL:EFB27082.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB27082.1};
RN   [1] {ECO:0000313|EMBL:EFB27082.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; GL192446; EFB27082.1; -; Genomic_DNA.
DR   RefSeq; XP_002915906.1; XM_002915860.3.
DR   RefSeq; XP_011218855.1; XM_011220553.2.
DR   GeneID; 100476294; -.
DR   KEGG; aml:100476294; -.
DR   CTD; 3981; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000007831; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG091G03K0; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      355    489       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      654    743       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      845    911       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   NON_TER     911    911       {ECO:0000313|EMBL:EFB27082.1}.
SQ   SEQUENCE   911 AA;  104150 MW;  103EDFCADBE593E1 CRC64;
     MAASHTSPTV ASRVPFADLC STLERIQRSR ERAAKIRHFR EFLDSWRRFH DALHKNQRDV
     SDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RGGKDALKLL NYRTPTGTRA
     DAGDFATIAY FVLKPRCLQK GSLTIQQVND ILDSIASNNS ARRKDLIKKS LLQLISQSSA
     LEQKWLIRMI VKDLKLGFSE QSVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI
     TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHRQGDVYQY FSRNGYNYTD
     QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD IKRMVEDSDL
     QTCYCVFDVL MVNNKKLGRE TLKKRHEILT SVFTPIPGRI EIVQKTQAHT QKEVIDALNE
     AIDKREEGIM IKHPLSIYKP DKRGEGWLKI KPEYVDGLMD ELDILIVGGY WGKGSRGGMM
     SHFLCAVAEK PPPGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKAPPSSILC
     GTEKPEVYIE PCHSVIVQVK ATEIVSSDMY KAGCTLRFPR IERIREDKEW HECTTVDDLE
     QLRGKASGKL ASKHLYVGDD DEPQEKKRKA APKVKKVIGI IEHLKAPNLS NVNKVCNIFE
     DVEFCVMSGT GSHPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIISSNKHDV
     VKPEWLLECF KTKSCVPWQP RFMIHMCPST KEHFAREYDH YGDSYFIDTD LNQLKEVFSG
     IKNSGEQTPG EMASVIAHLE FRYSWDRCPL SMFRQHIIYV DVYAVINDLS TKIEGTRLAV
     MGLELRFHGA KVVSRLAQGV SHVIVGEDRS RVADLKAFRR TLKRKFKILQ QDWVTDSIDK
     CELQEENRYL V
//
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