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Database: UniProt/TrEMBL
Entry: D2P869_LISM2
LinkDB: D2P869_LISM2
Original site: D2P869_LISM2 
ID   D2P869_LISM2            Unreviewed;       131 AA.
AC   D2P869;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   01-OCT-2014, entry version 31.
DE   RecName: Full=Regulatory protein Spx {ECO:0000256|HAMAP-Rule:MF_01132};
GN   Name=spxA {ECO:0000256|HAMAP-Rule:MF_01132,
GN   ECO:0000313|EMBL:ADB72186.1};
GN   OrderedLocusNames=LM5923_2345 {ECO:0000313|EMBL:ADB72186.1};
OS   Listeria monocytogenes serotype 1/2a (strain 08-5923).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=637381 {ECO:0000313|EMBL:ADB72186.1, ECO:0000313|Proteomes:UP000006922};
RN   [1] {ECO:0000313|EMBL:ADB72186.1, ECO:0000313|Proteomes:UP000006922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=08-5923 {ECO:0000313|EMBL:ADB72186.1,
RC   ECO:0000313|Proteomes:UP000006922};
RX   PubMed=20167121; DOI=10.1186/1471-2164-11-120;
RA   Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H.,
RA   Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.;
RT   "High-throughput genome sequencing of two Listeria monocytogenes
RT   clinical isolates during a large foodborne outbreak.";
RL   BMC Genomics 11:120-120(2010).
CC   -!- FUNCTION: Interferes with activator-stimulated transcription by
CC       interaction with the RNA polymerase alpha-CTD. May function to
CC       globally reduce transcription of genes involved in growth- and
CC       development-promoting processes and to increase transcription of
CC       genes involved in thiol homeostasis, during periods of extreme
CC       stress. {ECO:0000256|HAMAP-Rule:MF_01132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01132}.
CC   -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01132}.
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DR   EMBL; CP001604; ADB72186.1; -; Genomic_DNA.
DR   RefSeq; YP_003417548.1; NC_013768.1.
DR   ProteinModelPortal; D2P869; -.
DR   SMR; D2P869; 1-118.
DR   EnsemblBacteria; ADB72186; ADB72186; LM5923_2345.
DR   GeneID; 8759139; -.
DR   KEGG; lmy:LM5923_2345; -.
DR   PATRIC; 32258538; VBILisMon5116_2364.
DR   HOGENOM; HOG000059715; -.
DR   KO; K16509; -.
DR   OMA; RPIIMDD; -.
DR   BioCyc; LMON637381:GH7Z-2387-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.30.10; -; 1.
DR   HAMAP; MF_01132; SpxA; 1.
DR   InterPro; IPR006660; Arsenate_reductase-like.
DR   InterPro; IPR023731; Spx.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR   Pfam; PF03960; ArsC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01617; arsC_related; 1.
DR   PROSITE; PS51353; ARSC; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006922};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01132};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01132};
KW   Redox-active center {ECO:0000256|HAMAP-Rule:MF_01132};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01132};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01132}.
FT   DISULFID     10     13       Redox-active. {ECO:0000256|HAMAP-Rule:
FT                                MF_01132}.
SQ   SEQUENCE   131 AA;  15582 MW;  67181E1BA6CD9444 CRC64;
     MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR
     SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT
     YQLREAQKMV N
//
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