ID D2P869_LISM2 Unreviewed; 131 AA.
AC D2P869;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 01-MAY-2013, entry version 26.
DE RecName: Full=Regulatory protein spx;
GN Name=spxA; OrderedLocusNames=LM5923_2345;
OS Listeria monocytogenes serotype 1/2a (strain 08-5923).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=637381;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=08-5923;
RX PubMed=20167121; DOI=10.1186/1471-2164-11-120;
RA Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H.,
RA Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.;
RT "High-throughput genome sequencing of two Listeria monocytogenes
RT clinical isolates during a large foodborne outbreak.";
RL BMC Genomics 11:120-120(2010).
CC -!- FUNCTION: Interferes with activator-stimulated transcription by
CC interaction with the RNA polymerase alpha-CTD. May function to
CC globally reduce transcription of genes involved in growth- and
CC development-promoting processes and to increase transcription of
CC genes involved in thiol homeostasis, during periods of extreme
CC stress (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
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DR EMBL; CP001604; ADB72186.1; -; Genomic_DNA.
DR RefSeq; YP_003417548.1; NC_013768.1.
DR ProteinModelPortal; D2P869; -.
DR SMR; D2P869; 1-118.
DR EnsemblBacteria; ADB72186; ADB72186; LM5923_2345.
DR GeneID; 8759139; -.
DR KEGG; lmy:LM5923_2345; -.
DR PATRIC; 32258538; VBILisMon5116_2364.
DR HOGENOM; HOG000059715; -.
DR KO; K16509; -.
DR OMA; RPIIMDD; -.
DR BioCyc; LMON637381:GH7Z-2341-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR HAMAP; MF_01132; SpxA; 1; -.
DR InterPro; IPR006660; Arsenate_reductase-like.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR023731; Tscrpt_reg_Spx.
DR InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR Pfam; PF03960; ArsC; 1.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR01617; arsC_related; 1.
DR PROSITE; PS51353; ARSC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Disulfide bond; Redox-active center;
KW Transcription; Transcription regulation.
FT DISULFID 10 13 Redox-active (By similarity).
SQ SEQUENCE 131 AA; 15582 MW; 67181E1BA6CD9444 CRC64;
MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR
SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT
YQLREAQKMV N
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