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Database: UniProt/TrEMBL
Entry: D2PD39_SULID
LinkDB: D2PD39_SULID
Original site: D2PD39_SULID 
ID   D2PD39_SULID            Unreviewed;       332 AA.
AC   D2PD39;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   11-JUN-2014, entry version 25.
DE   RecName: Full=Probable methylcobalamin:homocysteine methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Methionine synthase;
GN   Name=metE; OrderedLocusNames=LD85_1953;
OS   Sulfolobus islandicus (strain L.D.8.5 / Lassen #2).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=425944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.D.8.5 / Lassen #2;
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group from
CC       methylcobalamin and methylcobinamide to homocysteine resulting in
CC       methionine formation (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway.
CC   -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine
CC       synthase family.
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DR   EMBL; CP001731; ADB87609.1; -; Genomic_DNA.
DR   RefSeq; YP_003419979.1; NC_013769.1.
DR   ProteinModelPortal; D2PD39; -.
DR   EnsemblBacteria; ADB87609; ADB87609; LD85_1953.
DR   GeneID; 8761787; -.
DR   KEGG; sii:LD85_1953; -.
DR   HOGENOM; HOG000140559; -.
DR   KO; K00549; -.
DR   OMA; RVWGNAY; -.
DR   BioCyc; SISL425944:GHS5-1948-MONOMER; -.
DR   UniPathway; UPA00051; -.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00288; MetE; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR022921; MetE_arc.
DR   Pfam; PF01717; Meth_synt_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Metal-binding;
KW   Methionine biosynthesis; Methyltransferase; Transferase; Zinc.
FT   METAL       211    211       Zinc (By similarity){EA3}.
FT   METAL       213    213       Zinc (By similarity){EA3}.
FT   METAL       296    296       Zinc (By similarity){EA3}.
SQ   SEQUENCE   332 AA;  38258 MW;  E1FBBFC249BFF2C1 CRC64;
     MSKLPLLPTT VIGSYPRPKW LRESIRLHKA GKISDEDLQE AFNDAVIAVL KDHYNAGVDV
     PTDGEVRRDE MVEFFAERIK GFKFYGPVRV WGTAYYRKPS VVSKIEYKKP MLVDEFTFAK
     SVSYTDNLKI TITGPYTIAE WSYNEYYKNK KDLVFDLAKA INQEIKNLVE AGAKIIQIDE
     PALHTRREDV SWGVEAVNEA VKGVNAKLVM HICYGEYSFV APYLNELKVD QINFAFKIYN
     YKPLELLKRY GFDKELGAGV IDVHNRRIET SEEVANDIRK ILEYFTPEKV WINPDCGLKL
     LSRKIAYQKL VSMVEGTKVV REELKRKGYS VD
//
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