GenomeNet

Database: UniProt/TrEMBL
Entry: D2PLK6_KRIFD
LinkDB: D2PLK6_KRIFD
Original site: D2PLK6_KRIFD 
ID   D2PLK6_KRIFD            Unreviewed;       739 AA.
AC   D2PLK6;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ADB30635.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ADB30635.1};
GN   OrderedLocusNames=Kfla_1537 {ECO:0000313|EMBL:ADB30635.1};
OS   Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Kribbella.
OX   NCBI_TaxID=479435 {ECO:0000313|EMBL:ADB30635.1, ECO:0000313|Proteomes:UP000007967};
RN   [1] {ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Saunders E., Brettin T., Detter J.C., Han C., Larimer F.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Kribbella flavida DSM 17836.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001736; ADB30635.1; -; Genomic_DNA.
DR   RefSeq; WP_012919191.1; NC_013729.1.
DR   ProteinModelPortal; D2PLK6; -.
DR   STRING; 479435.Kfla_1537; -.
DR   EnsemblBacteria; ADB30635; ADB30635; Kfla_1537.
DR   KEGG; kfl:Kfla_1537; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; KFLA479435:GI0F-1520-MONOMER; -.
DR   Proteomes; UP000007967; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007967};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ADB30635.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007967}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79307 MW;  A57AE0CFC56DD3CB CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIQAYA AQAGVAVETR DISLAGRIVA LFGEYLREDQ
     RITDDLGELG ELAKTPAANI IKLPNVSASI PQLKAAIAEL QSQGYALPDY PDEPKTDEER
     EIQARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTPDNK TNVATMGTDD
     FRSTEKSAVI PADTTLRIEL TGDDGSTTVL RESVPVLAGE VVDASVMHVA PLREFLTAQV
     ARAKAEDVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA SYGETLAKAG LTPNDGLGGI
     LAGLAALPEG PAIKASFDAE LADGPQLAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEHD TLAVLPDSSY AGIYQVVLDD CRANGAFDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEVPTT GTVRVVDADG TVVLEQTVSA GDIFRACQTK DAPVRDWVKL AVTRARATGD
     PAVFWLDETR PHDANLIAKV NEYLTEHDTD GLALRILPPV EAIAFSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALAA SFEHLAQTTG NARAQVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA KQTDDADLAT TFAPLAETLA GNEQTIVEEL LAVQGNPVEL GGYYHPDPAL
     AAAAMRPSKT WNDALATLA
//
DBGET integrated database retrieval system