ID   D2R1Q2_PIRSD            Unreviewed;       207 AA.
AC   D2R1Q2;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   01-MAY-2013, entry version 17.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=Psta_2097;
OS   Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) (Pirella
OS   staleyi).
OC   Bacteria; Planctomycetes; Planctomycetia; Planctomycetales;
OC   Planctomycetaceae; Pirellula.
OX   NCBI_TaxID=530564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27377 / DSM 6068 / ICPB 4128;
RX   PubMed=21304671; DOI=10.4056/sigs.51657;
RA   Clum A., Tindall B.J., Sikorski J., Ivanova N., Mavrommatis K.,
RA   Lucas S., Glavina del Rio T., Nolan M., Chen F., Tice H., Pitluck S.,
RA   Cheng J.F., Chertkov O., Brettin T., Han C., Detter J.C.,Kuske C.,
RA   Bruce D., Goodwin L., Ovchinikova G., Pati A., Mikhailova N., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Chain P., Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Pirellula staleyi type strain (ATCC
RT   27377).";
RL   Stand. Genomic Sci. 1:308-316(2009).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001848; ADB16771.1; -; Genomic_DNA.
DR   RefSeq; YP_003370631.1; NC_013720.1.
DR   EnsemblBacteria; ADB16771; ADB16771; Psta_2097.
DR   GeneID; 8706031; -.
DR   KEGG; psl:Psta_2097; -.
DR   PATRIC; 32287938; VBIPirSta4342_2196.
DR   HOGENOM; HOG000229078; -.
DR   KO; K00943; -.
DR   BioCyc; PSTA530564:GHPR-2116-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; PTHR10344; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND       7     14       ATP (By similarity).
SQ   SEQUENCE   207 AA;  22605 MW;  194E046D6F39C1FF CRC64;
     MFLSFDGVDG AGKSTQIRLL AEWLAARSLE VVVCRDPGGT PLGEKLRSIL LDDHETPIHR
     RSEMLLFMAS RAQLVEEVIR PALEAGKVVI SDRFLLATAV YQAHAGGLVA DDVWTVGKVA
     VGGMMPARVL LLDMPAAEAS KRIARAHDRM ESQGLAYLER VRQGFLLEAE RDPQTIRAID
     AARDPQAVHA DVVAAVEPLL LAREPLR
//