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Database: UniProt/TrEMBL
Entry: D2RCL2_GARV4
LinkDB: D2RCL2_GARV4
Original site: D2RCL2_GARV4 
ID   D2RCL2_GARV4            Unreviewed;       918 AA.
AC   D2RCL2;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|SAAS:SAAS00635171};
DE            EC=4.1.1.31 {ECO:0000256|SAAS:SAAS00635171};
GN   Name=ppc {ECO:0000313|EMBL:ADB14120.1};
GN   OrderedLocusNames=HMPREF0424_0018 {ECO:0000313|EMBL:ADB14120.1};
OS   Gardnerella vaginalis (strain 409-05).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Gardnerella.
OX   NCBI_TaxID=553190 {ECO:0000313|EMBL:ADB14120.1, ECO:0000313|Proteomes:UP000001888};
RN   [1] {ECO:0000313|Proteomes:UP000001888}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=409-05 {ECO:0000313|Proteomes:UP000001888};
RX   PubMed=20865041; DOI=10.1371/journal.pone.0012411;
RA   Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M.,
RA   Sutton G., Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X.,
RA   Gibbs R.A., Leigh S.R., Stumpf R., White B.A., Highlander S.K.,
RA   Nelson K.E., Wilson B.A.;
RT   "Comparative genomics of Gardnerella vaginalis strains reveals
RT   substantial differences in metabolic and virulence potential.";
RL   PLoS ONE 5:E12411-E12411(2010).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle.
CC       {ECO:0000256|SAAS:SAAS00730191}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|SAAS:SAAS00635165}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00635164};
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|SAAS:SAAS00635168}.
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DR   EMBL; CP001849; ADB14120.1; -; Genomic_DNA.
DR   RefSeq; WP_012913687.1; NC_013721.1.
DR   STRING; 553190.HMPREF0424_0018; -.
DR   EnsemblBacteria; ADB14120; ADB14120; HMPREF0424_0018.
DR   GeneID; 29691795; -.
DR   KEGG; gva:HMPREF0424_0018; -.
DR   eggNOG; ENOG4105CCA; Bacteria.
DR   eggNOG; COG2352; LUCA.
DR   HOGENOM; HOG000238647; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   Proteomes; UP000001888; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF00311; PEPcase; 2.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|SAAS:SAAS00635173};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001888};
KW   Kinase {ECO:0000313|EMBL:ADB14120.1};
KW   Lyase {ECO:0000256|SAAS:SAAS00635169, ECO:0000313|EMBL:ADB14120.1};
KW   Magnesium {ECO:0000256|SAAS:SAAS00635157};
KW   Pyruvate {ECO:0000313|EMBL:ADB14120.1};
KW   Transferase {ECO:0000313|EMBL:ADB14120.1}.
FT   ACT_SITE    181    181       {ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    580    580       {ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   918 AA;  103055 MW;  B167FED09002C5BD CRC64;
     MATENQQVTP ADATIVTSGL GRKGPEERDL PASLKQDMDL CLHILRDVLG EFDEKLLAVF
     DDVRLNAVEA SAAHFAQMVD AKVTADDGLS KAVSKLNGMN LHDTQLLARA FATYFHLANL
     CEENYRVSVL HQRECEVEDS LPVDPVNELT CAYHKLLTEM SPAEAKELLA KLEFHPVFTA
     HPTEARRKAV AGKIRRISQL LSEHHRLGGS DKRENYRRLY NEIDALLRTS PIALKKPTPV
     EESDTILDIF DATLFDTIPV VYRRFDDWLL GKKAGLVPPR CPAFFHPGSW IGSDRDGNPN
     VTAKVSRQVA RKFSDHVLAA LENRTREVGK CLTMETRTTP PSVELLELWN RQREMSEQLT
     ENASDVSNSE PHRAVMLVMA DRLHRTISRD TDLMYHSCED FIEDLQIVQR SLAEGGDPRA
     AYGPLQDLIW QAQTFGFHMV EMEFRQHSLV HSRALEDIRE HGLHGERGPL QPMTREVLDT
     FRALGAIQKR NGMRAARRYI ISFAKSAQHV RDVFELNRLA FAHPQDAPTI DVIPLFEQLE
     DLQNSVNVLE EIIKIPEVQA RLKATGRKME VMLGYSDSSK DAGPTSATLA LHSAQERIAK
     WAKKHDIDLT LFHGRGGAVG RGGGPANRAV LAQPVGSVNC RFKLTEQGEV IFARYGNPIL
     AIRHVESVAS ATLLQSSPSV EKTNTDMTKK YADMAAKLDV AAHERFLDLL QTDDFTPWFS
     TVTPLSEIGL LPIGSRPAKR GLGAKSLDDL RTIPWVFSWA QARINLAAWY GLGTACEKFG
     DLETLRRAYE EWPLFSTFID NIEMSLAKTD ERIARMYLSL GDREDLSDKV LSEMQLTRKW
     VLQIVDDKWP LQHRHVLGQA IRVRSPYVDA LSVIQSLALH KLRNKVDKEE LSESQQAEFI
     YLILCTVSGV AAGLQNTG
//
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