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Database: UniProt/TrEMBL
Entry: D3EN78_ATETH
LinkDB: D3EN78_ATETH
Original site: D3EN78_ATETH 
ID   D3EN78_ATETH            Unreviewed;       404 AA.
AC   D3EN78;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   05-JUL-2017, entry version 47.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=UCYN_01790 {ECO:0000313|EMBL:ADB94928.1};
OS   Atelocyanobacterium thalassa (isolate ALOHA).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Candidatus Atelocyanobacterium.
OX   NCBI_TaxID=1453429 {ECO:0000313|Proteomes:UP000001405};
RN   [1] {ECO:0000313|EMBL:ADB94928.1, ECO:0000313|Proteomes:UP000001405}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ALOHA {ECO:0000313|Proteomes:UP000001405};
RX   PubMed=20173737; DOI=10.1038/nature08786;
RA   Tripp H.J., Bench S.R., Turk K.A., Foster R.A., Desany B.A., Niazi F.,
RA   Affourtit J.P., Zehr J.P.;
RT   "Metabolic streamlining in an open-ocean nitrogen-fixing
RT   cyanobacterium.";
RL   Nature 464:90-94(2010).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP001842; ADB94928.1; -; Genomic_DNA.
DR   ProteinModelPortal; D3EN78; -.
DR   EnsemblBacteria; ADB94928; ADB94928; UCYN_01790.
DR   KEGG; cyu:UCYN_01790; -.
DR   PATRIC; fig|713887.8.peg.166; -.
DR   eggNOG; ENOG4107UKP; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   HOGENOM; HOG000281566; -.
DR   KO; K00627; -.
DR   OrthoDB; POG091H04EL; -.
DR   Proteomes; UP000001405; Chromosome.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR004167; E3-bd.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ADB94928.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001405};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00100674};
KW   Pyruvate {ECO:0000313|EMBL:ADB94928.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001405};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ADB94928.1}.
FT   DOMAIN        1     71       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
SQ   SEQUENCE   404 AA;  44344 MW;  C1BFB4757A5D25AE CRC64;
     MPALSSTMTE GKIISWEKSP GDKVTKGETV VIIESDKADM DVESFYDGYL ATILVKAGEE
     APVGEAIALI AETKEEITNA QDKAPSIFKK SNFSSKIEEK IIEKNSTESY QGESNSFVDT
     NNLEKFKGRI IASPRAKKIA RDLGIDLNKI KGSGPYGRIV TEDLQDKQEN KTIVDSKINT
     SQEVIPFSTM QKTVAKNMLA TLGIPVFRVS YDINTEQLDK LYQSIKTKGV TMTVILAKAI
     ALTLRKHSLI NAKYESSGIQ YCESINIAIA VAMPDGGLIT PVLNNVDKTD IYSLSRIWKD
     LLSRARTREL KPSEYSNGTF TLSNLGMFGV DTFDAILPPE QGSILAIGAS KPHVIAISDK
     LFGIQNKMTV NITCDHRIIY GSHAASFLQD LAKVIESNTQ LLTM
//
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