ID   D3R274_CLOB3            Unreviewed;       308 AA.
AC   D3R274;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   01-MAY-2013, entry version 25.
DE   RecName: Full=Proline iminopeptidase;
DE            EC=3.4.11.5;
GN   Name=pip; OrderedLocusNames=HMPREF0868_0978;
OS   Clostridiales genomosp. BVAB3 (strain UPII9-5).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales.
OX   NCBI_TaxID=699246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UPII9-5;
RA   Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Strausberg R.L., Nelson K.E.;
RT   "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Release of N-terminal proline from a peptide.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
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DR   EMBL; CP001850; ADC91251.1; -; Genomic_DNA.
DR   RefSeq; YP_003475281.1; NC_013895.2.
DR   ProteinModelPortal; D3R274; -.
DR   EnsemblBacteria; ADC91251; ADC91251; HMPREF0868_0978.
DR   GeneID; 8811529; -.
DR   KEGG; clo:HMPREF0868_0978; -.
DR   PATRIC; 35310468; VBICloGen152872_0955.
DR   HOGENOM; HOG000171480; -.
DR   KO; K01259; -.
DR   BioCyc; CGEN699246:GI5D-748-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002410; Peptidase_S33.
DR   InterPro; IPR005944; Pro_iminopeptidase.
DR   PANTHER; PTHR10992:SF12; PTHR10992:SF12; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF006431; Pept_S33; 1.
DR   PRINTS; PR00793; PROAMNOPTASE.
DR   TIGRFAMs; TIGR01249; pro_imino_pep_1; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Complete proteome; Hydrolase; Protease.
FT   ACT_SITE    110    110       Nucleophile (By similarity).
FT   ACT_SITE    261    261       By similarity.
FT   ACT_SITE    288    288       Proton donor (By similarity).
SQ   SEQUENCE   308 AA;  34983 MW;  50E2A2A9B4A76C5A CRC64;
     MLNLFPEIKP YHTEYLQVDP IHRIFFTLSG NPAGRPVIYV HGGPGCGCSA IAQRFFDPQY
     YHIITVDQRG CGQSTPFLEI RNNTTADLAS DMEKIRQYLS IDKWIVHGGS WGTTLSLYYA
     ENYPEAVDAL VLRGIFLGRD EDIKWLYQGG AGQFFPEAYS AFTSLLPANC SDNIAYYYQK
     LTNGNDEDLM KYGKAFSTFE NSVTTLKPKA INSDITPLDL AMARMECHYF VNHCFMPENY
     ILNNVHRIAS IPTFIVHGRY DVDCRPEGAY LLAQKLPSAK LVFTISGHSS MEPEIIDQLI
     RIQKEMQR
//