ID D3T6P6_THEIA Unreviewed; 312 AA.
AC D3T6P6;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 01-MAY-2013, entry version 23.
DE RecName: Full=Cobalamin biosynthesis protein CobD;
DE Flags: Precursor;
GN Name=cobD; OrderedLocusNames=Thit_0344;
OS Thermoanaerobacter italicus (strain DSM 9252 / Ab9).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=580331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 9252 / Ab9;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Hemme C.L., Woyke T.;
RT "Complete sequence of Thermoanaerobacter italicus Ab9.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (By similarity).
CC -!- SIMILARITY: Belongs to the CobD/CbiB family.
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DR EMBL; CP001936; ADD01659.1; -; Genomic_DNA.
DR RefSeq; YP_003476221.1; NC_013921.1.
DR EnsemblBacteria; ADD01659; ADD01659; Thit_0344.
DR GeneID; 8820652; -.
DR KEGG; tit:Thit_0344; -.
DR PATRIC; 32495646; VBITheIta22270_0358.
DR HOGENOM; HOG000290070; -.
DR KO; K02227; -.
DR OMA; REFGWAS; -.
DR UniPathway; UPA00148; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:cobalamin-transporting ATPase activity; IEA:HAMAP.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1; -.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR Pfam; PF03186; CobD_Cbib; 1.
DR TIGRFAMs; TIGR00380; cobD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cobalamin biosynthesis; Complete proteome; Membrane;
KW Transmembrane; Transmembrane helix.
FT TRANSMEM 52 72 Helical; (By similarity).
FT TRANSMEM 73 93 Helical; (By similarity).
FT TRANSMEM 151 171 Helical; (By similarity).
FT TRANSMEM 201 221 Helical; (By similarity).
SQ SEQUENCE 312 AA; 34525 MW; 3D43024B6F337650 CRC64;
MEVVLAYLLD LLIGDPEGYP HPVRIIGKVV SHLESILRKY AKSNRALKIA GFILCGLTVT
LAFAATYVLL YIAGLIHPYL KYALDVLIIY TCLATKDLDK AAGKVYEALT KGDIVEARRR
LSYIVSRDTD RLDVENISRG AIETVAENIS DGIIAPMFYA FIGGAPLAVF YKAASTLDSM
VGYRNEKYLD LGFASAKLDD ILNFIPARIT GFLIVVAAFL LGYDYKNSWR IFLRDRLKHQ
SPNSAHGEAA VAGALNIQLG GLNYYFGKPE IKPTLGDGKE KITPQHMKDS IKIMYMTSSL
GLVVFYIGRR LI
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