ID D3UQH9_LISSS Unreviewed; 131 AA.
AC D3UQH9;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 01-MAY-2013, entry version 22.
DE RecName: Full=Regulatory protein spx;
GN Name=spxA; OrderedLocusNames=lse_2171;
OS Listeria seeligeri serovar 1/2b (strain ATCC 35967 / DSM 20751 / CIP
OS 100100 / SLCC 3954).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=683837;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954;
RX PubMed=20061480; DOI=10.1128/JB.01415-09;
RA Steinweg C., Kuenne C.T., Billion A., Mraheil M.A., Domann E.,
RA Ghai R., Barbuddhe S.B., Karst U., Goesmann A., Puhler A.,
RA Weisshaar B., Wehland J., Lampidis R., Kreft J., Goebel W.,
RA Chakraborty T., Hain T.;
RT "Complete genome sequence of Listeria seeligeri, a nonpathogenic
RT member of the genus Listeria.";
RL J. Bacteriol. 192:1473-1474(2010).
CC -!- FUNCTION: Interferes with activator-stimulated transcription by
CC interaction with the RNA polymerase alpha-CTD. May function to
CC globally reduce transcription of genes involved in growth- and
CC development-promoting processes and to increase transcription of
CC genes involved in thiol homeostasis, during periods of extreme
CC stress (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; FN557490; CBH28322.1; -; Genomic_DNA.
DR RefSeq; YP_003465404.1; NC_013891.1.
DR ProteinModelPortal; D3UQH9; -.
DR SMR; D3UQH9; 1-118.
DR EnsemblBacteria; CBH28322; CBH28322; lse_2171.
DR GeneID; 9080888; -.
DR KEGG; lsg:lse_2171; -.
DR PATRIC; 32264308; VBILisSee138575_2168.
DR HOGENOM; HOG000059715; -.
DR KO; K16509; -.
DR BioCyc; LSEE683837:GI10-1593-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR HAMAP; MF_01132; SpxA; 1; -.
DR InterPro; IPR006660; Arsenate_reductase-like.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR023731; Tscrpt_reg_Spx.
DR InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR Pfam; PF03960; ArsC; 1.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR01617; arsC_related; 1.
DR PROSITE; PS51353; ARSC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Disulfide bond; Redox-active center;
KW Transcription; Transcription regulation.
FT DISULFID 10 13 Redox-active (By similarity).
SQ SEQUENCE 131 AA; 15582 MW; 67181E1BA6CD9444 CRC64;
MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR
SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT
YQLREAQKMV N
//
