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Database: UniProt/TrEMBL
Entry: D3UQH9_LISSS
LinkDB: D3UQH9_LISSS
Original site: D3UQH9_LISSS 
ID   D3UQH9_LISSS            Unreviewed;       131 AA.
AC   D3UQH9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   14-MAY-2014, entry version 26.
DE   RecName: Full=Regulatory protein Spx;
GN   Name=spxA; OrderedLocusNames=lse_2171;
OS   Listeria seeligeri serovar 1/2b (strain ATCC 35967 / DSM 20751 / CIP
OS   100100 / SLCC 3954).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=683837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35967 / DSM 20751 / CIP 100100 / SLCC 3954;
RX   PubMed=20061480; DOI=10.1128/JB.01415-09;
RA   Steinweg C., Kuenne C.T., Billion A., Mraheil M.A., Domann E.,
RA   Ghai R., Barbuddhe S.B., Karst U., Goesmann A., Puhler A.,
RA   Weisshaar B., Wehland J., Lampidis R., Kreft J., Goebel W.,
RA   Chakraborty T., Hain T.;
RT   "Complete genome sequence of Listeria seeligeri, a nonpathogenic
RT   member of the genus Listeria.";
RL   J. Bacteriol. 192:1473-1474(2010).
CC   -!- FUNCTION: Interferes with activator-stimulated transcription by
CC       interaction with the RNA polymerase alpha-CTD. May function to
CC       globally reduce transcription of genes involved in growth- and
CC       development-promoting processes and to increase transcription of
CC       genes involved in thiol homeostasis, during periods of extreme
CC       stress (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
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DR   EMBL; FN557490; CBH28322.1; -; Genomic_DNA.
DR   RefSeq; YP_003465404.1; NC_013891.1.
DR   ProteinModelPortal; D3UQH9; -.
DR   SMR; D3UQH9; 1-118.
DR   EnsemblBacteria; CBH28322; CBH28322; lse_2171.
DR   GeneID; 9080888; -.
DR   KEGG; lsg:lse_2171; -.
DR   PATRIC; 32264308; VBILisSee138575_2168.
DR   HOGENOM; HOG000059715; -.
DR   KO; K16509; -.
DR   OMA; RPIIMDD; -.
DR   BioCyc; LSEE683837:GI10-2228-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.30.10; -; 1.
DR   HAMAP; MF_01132; SpxA; 1.
DR   InterPro; IPR006660; Arsenate_reductase-like.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR023731; Tscrpt_reg_Spx.
DR   InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR   Pfam; PF03960; ArsC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01617; arsC_related; 1.
DR   PROSITE; PS51353; ARSC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Disulfide bond; Redox-active center;
KW   Transcription; Transcription regulation.
FT   DISULFID     10     13       Redox-active (By similarity).
SQ   SEQUENCE   131 AA;  15582 MW;  67181E1BA6CD9444 CRC64;
     MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR
     SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT
     YQLREAQKMV N
//
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