ID   D3YT91_CAEEL            Unreviewed;       533 AA.
AC   D3YT91;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 91.
DE   SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|EMBL:CBK19454.1};
GN   Name=rga-5 {ECO:0000313|EMBL:CBK19454.1,
GN   ECO:0000313|WormBase:H08M01.2c};
GN   ORFNames=CELE_H08M01.2 {ECO:0000313|EMBL:CBK19454.1}, H08M01.2
GN   {ECO:0000313|WormBase:H08M01.2c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CBK19454.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CBK19454.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CBK19454.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
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DR   EMBL; BX284604; CBK19454.1; -; Genomic_DNA.
DR   RefSeq; NP_001255759.1; NM_001268830.1.
DR   AlphaFoldDB; D3YT91; -.
DR   SMR; D3YT91; -.
DR   EnsemblMetazoa; H08M01.2c.1; H08M01.2c.1; WBGene00010374.
DR   GeneID; 178348; -.
DR   AGR; WB:WBGene00010374; -.
DR   WormBase; H08M01.2c; CE44621; WBGene00010374; rga-5.
DR   HOGENOM; CLU_004268_0_0_1; -.
DR   OrthoDB; 2879256at2759; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010374; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   ExpressionAtlas; D3YT91; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0050770; P:regulation of axonogenesis; IBA:GO_Central.
DR   GO; GO:0008361; P:regulation of cell size; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          340..529
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          42..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   533 AA;  59191 MW;  40AB90838742AA26 CRC64;
     MMEFLHDICD GQVQPITSNA NSEIDSIEND RPSILSSSGI QLLAKPDSSN RSRRPKPVVN
     SNLRNRVTRT DPLIMSHFYS QPIEIQPAPL ATPEAVDFSP AYSLVNDAVH TVIQVNGSTP
     LKSPPTFHSY ESSTPDSRST TSTVSGSSPA PRAVSADVTR RSRTSNVSLS TDSINRLHRT
     SNLFQLRPEA ALTAEQKRKS LSIESLTKVP EKEKGNRFVR KVATSFRLRK SLLDTTCDGE
     SDKKENKKKT STTTSPEQIS SFLEKMATRS LPQSPRTDRK AKLYSSLNST TEKVSNVLSW
     LPSKTSKKLM KNKSATHDLS TSLINYPAST STQGVIAANE TLETLCSKSP SQIPIYLEKC
     IQFIEQNGGF EQEGLYRVPG NQTHLAEVEK RFLKYGEFDV SSFDTPVHVA ATALKSFFSC
     LPESLIPTAY HLRWKQIMMV SDDIKKIDGI RDALAILPVS NQKVLQYLVT HLTKVSCSPK
     TVMNSNNLSK VWTPTLFRPV FASYEELSSG IIAFQLALEM LIFNSHSLFN QSF
//

ID   D3YT92_CAEEL            Unreviewed;       224 AA.
AC   D3YT92;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 87.
DE   SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|EMBL:CBK19455.1};
GN   Name=rga-5 {ECO:0000313|EMBL:CBK19455.1,
GN   ECO:0000313|WormBase:H08M01.2d};
GN   ORFNames=CELE_H08M01.2 {ECO:0000313|EMBL:CBK19455.1}, H08M01.2
GN   {ECO:0000313|WormBase:H08M01.2d};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CBK19455.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CBK19455.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CBK19455.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284604; CBK19455.1; -; Genomic_DNA.
DR   RefSeq; NP_001255760.1; NM_001268831.1.
DR   AlphaFoldDB; D3YT92; -.
DR   SMR; D3YT92; -.
DR   EnsemblMetazoa; H08M01.2d.1; H08M01.2d.1; WBGene00010374.
DR   GeneID; 178348; -.
DR   AGR; WB:WBGene00010374; -.
DR   WormBase; H08M01.2d; CE44576; WBGene00010374; rga-5.
DR   HOGENOM; CLU_004268_0_0_1; -.
DR   OrthoDB; 2879256at2759; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010374; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   ExpressionAtlas; D3YT92; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0050770; P:regulation of axonogenesis; IBA:GO_Central.
DR   GO; GO:0008361; P:regulation of cell size; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          31..220
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   224 AA;  25076 MW;  E23A216A999A46F4 CRC64;
     MKNKSATHDL STSLINYPAS TSTQGVIAAN ETLETLCSKS PSQIPIYLEK CIQFIEQNGG
     FEQEGLYRVP GNQTHLAEVE KRFLKYGEFD VSSFDTPVHV AATALKSFFS CLPESLIPTA
     YHLRWKQIMM VSDDIKKIDG IRDALAILPV SNQKVLQYLV THLTKVSCSP KTVMNSNNLS
     KVWTPTLFRP VFASYEELSS GIIAFQLALE MLIFNSHSLF NQSF
//

ID   O45611_CAEEL            Unreviewed;      1341 AA.
AC   O45611;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 3.
DT   27-MAR-2024, entry version 161.
DE   SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|EMBL:CAB07634.3};
GN   Name=rga-5 {ECO:0000313|EMBL:CAB07634.3,
GN   ECO:0000313|WormBase:H08M01.2b};
GN   ORFNames=CELE_H08M01.2 {ECO:0000313|EMBL:CAB07634.3}, H08M01.2
GN   {ECO:0000313|WormBase:H08M01.2b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB07634.3, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAB07634.3, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB07634.3,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284604; CAB07634.3; -; Genomic_DNA.
DR   PIR; T23061; T23061.
DR   RefSeq; NP_001023257.1; NM_001028086.3.
DR   AlphaFoldDB; O45611; -.
DR   SMR; O45611; -.
DR   STRING; 6239.H08M01.2b.1; -.
DR   EPD; O45611; -.
DR   PaxDb; 6239-H08M01-2b; -.
DR   PeptideAtlas; O45611; -.
DR   EnsemblMetazoa; H08M01.2b.1; H08M01.2b.1; WBGene00010374.
DR   GeneID; 178348; -.
DR   KEGG; cel:CELE_H08M01.2; -.
DR   UCSC; H08M01.2a; c. elegans.
DR   AGR; WB:WBGene00010374; -.
DR   WormBase; H08M01.2b; CE36176; WBGene00010374; rga-5.
DR   eggNOG; KOG4271; Eukaryota.
DR   GeneTree; ENSGT00940000154610; -.
DR   HOGENOM; CLU_004268_0_0_1; -.
DR   InParanoid; O45611; -.
DR   OMA; GFSECFE; -.
DR   OrthoDB; 2879256at2759; -.
DR   PhylomeDB; O45611; -.
DR   Reactome; R-CEL-416550; Sema4D mediated inhibition of cell attachment and migration.
DR   Reactome; R-CEL-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR   Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR   Reactome; R-CEL-9013148; CDC42 GTPase cycle.
DR   Reactome; R-CEL-9013149; RAC1 GTPase cycle.
DR   Reactome; R-CEL-9013405; RHOD GTPase cycle.
DR   Reactome; R-CEL-9013406; RHOQ GTPase cycle.
DR   Reactome; R-CEL-9013409; RHOJ GTPase cycle.
DR   Reactome; R-CEL-9013423; RAC3 GTPase cycle.
DR   Reactome; R-CEL-9035034; RHOF GTPase cycle.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010374; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   ExpressionAtlas; O45611; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0050770; P:regulation of axonogenesis; IBA:GO_Central.
DR   GO; GO:0008361; P:regulation of cell size; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   CDD; cd00882; Ras_like_GTPase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR045786; RhoGAP_pG1_pG2.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:O45611};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          640..822
FT                   /note="PG2 pseudoGTPase"
FT                   /evidence="ECO:0000259|PROSITE:PS51853"
FT   DOMAIN          1148..1337
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          850..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1044..1066
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1044..1059
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1341 AA;  151064 MW;  0978DDB7A84A9FB3 CRC64;
     MSSTSQTYSN STKIKEINVI VVGVSGSEAV KGPSGVGKSL LCNRFVRPAA DEFHREHSSV
     LSQIDFCGSP VINKDHWLYW GSRVLSNPES SASNILIRVA EQTEFLDDET FETIAGCSKS
     ENYCQRCCQT SLQSRDKLMY IQKEQLGLES EFPQQLLPNG KFNVDGFILA CDISKPTSAH
     LHSSHVLNIA KAISKTKKPV IIAFTKCDEA SEECKKNYLN LFYSTKELKH IMSHVPPVET
     SSVKNVNVEY LFGTLANLCL KSQKIVKKPL AYHEASLFVE QRNLHVKCCF STLLSQAVPL
     CTYPKKCLSW NQVLADIDRH PDLMNFVTVF GSRVAFEMYE RYVSEAKELW AINRLRTLVP
     RLFEIFQVFL DVVDLAEMEW SQARDFMRCH PLFHVLFESN EYNLEMWSPP SSFNKDEKSR
     LPSEILLLPE AAKVFEQFRL STLNLRLKHQ LGQEFEYLLN EIPQILPGCS METAFPLFQN
     FNVIKKLTPD IVTTVYDRFQ KKLMENARKQ LEECILEVSP GIQLQNLKIK SWKTPGLSHF
     DMSMDFNQKL ETVKNFLEVD DRYEWMRIMA GERDQIIVNH LPFIFDVSPV NCPSTDMCID
     LVGTSILNDF SEQNSTFCGS SGFSECFEAT RKNSGKNMPR IQISAMCGDQ LSIDSLAGAL
     FHNTLIRPSN YNFSNDGATF IEVLDENTQI WNNIEINMCS YHSWFHKNDS NPSESIDLND
     GYLFVYNSQR ASSFNYARCA IEKLAETNSV NFDCILLLAV VKGGGSDSMK LNLENLTEGA
     ELCKSIGARF SAIDFRKRKT KSNGINHQMM EFLHDICDGQ VQPITSNANS EIDSIENDRP
     SILSSSGIQL LAKPDSSNRS RRPKPVVNSN LRNRVTRTDP LIMSHFYSQP IEIQPAPLAT
     PEAVDFSPAY SLVNDAVHTV IQVNGSTPLK SPPTFHSYES STPDSRSTTS TVSGSSPAPR
     AVSADVTRRS RTSNVSLSTD SINRLHRTSN LFQLRPEAAL TAEQKRKSLS IESLTKVPEK
     EKGNRFVRKV ATSFRLRKSL LDTTCDGESD KKENKKKTST TTSPEQISSF LEKMATRSLP
     QSPRTDRKAK LYSSLNSTTE KVSNVLSWLP SKTSKKLMKN KSATHDLSTS LINYPASTST
     QGVIAANETL ETLCSKSPSQ IPIYLEKCIQ FIEQNGGFEQ EGLYRVPGNQ THLAEVEKRF
     LKYGEFDVSS FDTPVHVAAT ALKSFFSCLP ESLIPTAYHL RWKQIMMVSD DIKKIDGIRD
     ALAILPVSNQ KVLQYLVTHL TKVSCSPKTV MNSNNLSKVW TPTLFRPVFA SYEELSSGII
     AFQLALEMLI FNSHSLFNQS F
//