GenomeNet

Database: UniProt/TrEMBL
Entry: D3ZEB9_RAT
LinkDB: D3ZEB9_RAT
Original site: D3ZEB9_RAT 
ID   D3ZEB9_RAT              Unreviewed;       322 AA.
AC   D3ZEB9; F7J138;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   22-NOV-2017, entry version 57.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00904};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00904};
GN   Name=Kmt5a {ECO:0000313|Ensembl:ENSRNOP00000062763,
GN   ECO:0000313|RGD:1587560};
GN   Synonyms=LOC100909949 {ECO:0000313|RGD:1587560}, Pr-set7
GN   {ECO:0000313|EMBL:BAK43219.1}, Setd8 {ECO:0000313|RGD:1587560};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000062763, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000062763, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000062763,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:BAK43219.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:BAK43219.1};
RA   Osada S., Hashizume H., Gomita U., Imagawa M.;
RT   "Histone methyltransferase Pr-set7 represses the promoter activity of
RT   the tumor marker gene.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000062763}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000062763};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00904}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. PR/SET subfamily. {ECO:0000256|PROSITE-ProRule:PRU00904}.
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DR   EMBL; AABR07036310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07072291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB606422; BAK43219.1; -; mRNA.
DR   RefSeq; NP_001233594.1; NM_001246665.1.
DR   UniGene; Rn.8879; -.
DR   STRING; 10116.ENSRNOP00000062763; -.
DR   Ensembl; ENSRNOT00000066253; ENSRNOP00000062763; ENSRNOG00000001062.
DR   GeneID; 689820; -.
DR   KEGG; rno:689820; -.
DR   UCSC; RGD:1587560; rat.
DR   CTD; 387893; -.
DR   RGD; 1587560; Kmt5a.
DR   eggNOG; KOG1085; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00410000025501; -.
DR   KO; K11428; -.
DR   OMA; KQFSRGE; -.
DR   OrthoDB; EOG091G0UBI; -.
DR   Reactome; R-RNO-2299718; Condensation of Prophase Chromosomes.
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-RNO-6804760; Regulation of TP53 Activity through Methylation.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001062; -.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISO:RGD.
DR   GO; GO:0002039; F:p53 binding; ISO:RGD.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISO:RGD.
DR   GO; GO:0003714; F:transcription corepressor activity; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISO:RGD.
DR   GO; GO:0043516; P:regulation of DNA damage response, signal transduction by p53 class mediator; ISO:RGD.
DR   InterPro; IPR016858; Hist_H4-K20_MeTrfase.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF027717; Histone_H4-K20_mtfrase; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00904,
KW   ECO:0000313|EMBL:BAK43219.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00904};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00904,
KW   ECO:0000313|EMBL:BAK43219.1}.
FT   DOMAIN      186    307       SET. {ECO:0000259|PROSITE:PS50280}.
FT   REGION      196    198       S-adenosyl-L-methionine binding.
FT                                {ECO:0000256|PIRSR:PIRSR027717-1,
FT                                ECO:0000256|PROSITE-ProRule:PRU00904}.
FT   REGION      268    269       S-adenosyl-L-methionine binding.
FT                                {ECO:0000256|PIRSR:PIRSR027717-1,
FT                                ECO:0000256|PROSITE-ProRule:PRU00904}.
FT   BINDING     241    241       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PIRSR:PIRSR027717-1,
FT                                ECO:0000256|PROSITE-ProRule:PRU00904}.
SQ   SEQUENCE   322 AA;  36216 MW;  BB07F0BC32F9A066 CRC64;
     MVERRGPGRP RSDGENVFAG QSKIYAYMSP NKCSGMRSPL QEENSVAHHE VKCPGKPLAG
     IYRKREEKRN AGNVIRSAVK SEEQKSKDTR RGPLAPFPNQ KPEATEPPKT PPPSCDSTSV
     AVAKQALKKP LKGKQAPRKK SQGKTQQNRK LTDFYPVRRS SRKSKAELQS EERKKIDELI
     ESGKEEGMKI DLIDGKGRGV IATKRFSRGD FVVEYHGDLI EITDAKKREA LYAQDPSTGC
     YMYYFQYLSK TYCVDATQET NRLGRLINHS KCGNCQTKLH DIDGVPHLIL IASRDIAAGE
     ELLYDYGDRS KASIEAYPWL KH
//
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