ID D5E010_BACMQ Unreviewed; 413 AA.
AC D5E010;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 01-MAY-2013, entry version 24.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2;
DE EC=2.3.1.179;
GN Name=fabF; OrderedLocusNames=BMQ_0696;
OS Bacillus megaterium (strain ATCC 12872 / QMB1551).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=545693;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12872 / QMB1551;
RA Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K.,
RA Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J.,
RA Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J.,
RA Vary P.S.;
RT "Genome sequences of the industrial vitamin B12-producers B.
RT megaterium QM B1551 and DSM319 reveal new insights into the Bacillus
RT genome evolution and pan-genome structure.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC synthesis by the addition to an acyl acceptor of two carbons from
CC malonyl-ACP (By similarity).
CC -!- CATALYTIC ACTIVITY: (Z)-hexadec-11-enoyl-[acyl-carrier-protein] +
CC malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-
CC carrier-protein] + CO(2) + [acyl-carrier-protein].
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
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DR EMBL; CP001983; ADE67730.1; -; Genomic_DNA.
DR RefSeq; YP_003561164.1; NC_014019.1.
DR EnsemblBacteria; ADE67730; ADE67730; BMQ_0696.
DR GeneID; 8985134; -.
DR KEGG; bmq:BMQ_0696; -.
DR PATRIC; 35478025; VBIBacMeg35839_0688.
DR HOGENOM; HOG000060166; -.
DR KO; K09458; -.
DR BioCyc; BMEG545693:GHSY-1077-MONOMER; -.
DR UniPathway; UPA00094; -.
DR GO; GO:0033817; F:beta-ketoacyl-acyl-carrier-protein synthase II activity; IEA:EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR016038; Thiolase-like_subgr.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR PIRSF; PIRSF000447; KAS_II; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR TIGRFAMs; TIGR03150; fabF; 1.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Complete proteome; Fatty acid biosynthesis;
KW Lipid biosynthesis; Transferase.
SQ SEQUENCE 413 AA; 43544 MW; 1C58730E997371E5 CRC64;
MNKKRVVVTG LGGLTPIGND VETAWKNAVA GVSGVGPLTR LDADEFPAKV AAEVKDFNVE
DFIDRKEARK MDRFTQYAMV AALAAVKDAD LTITEEIAPN VGVWIGSGIG GMETFENQYS
TLLEKGARRV SPFFIPMMIP DMATGQVSIA LGAKGVNSCT VTACATGTNS IGDAFKVIQR
GDADVMVTGG TEAPITRLSI AGFCANKALS TNPDPATASR PFDKDRDGFV MGEGAGVIVL
EELEHALARG ARIYAEIVGY GSTGDAHHIT APAPGGEGGV RAMRHAIEDA GLQPSDIDYI
NAHGTSTGYN DKFETMAIKE VFGDHAQKVA ISSTKSMTGH LLGAAGGVEA IFSVKAIQDG
ILPPTINYQT PDEECDLDYI PNKARKQEVK AVLSNSLGFG GHNATIIFKK YEA
//
