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Database: UniProt/TrEMBL
Entry: D5E010_BACMQ
LinkDB: D5E010_BACMQ
Original site: D5E010_BACMQ 
ID   D5E010_BACMQ            Unreviewed;       413 AA.
AC   D5E010;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   16-OCT-2013, entry version 26.
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2;
DE            EC=2.3.1.179;
GN   Name=fabF; OrderedLocusNames=BMQ_0696;
OS   Bacillus megaterium (strain ATCC 12872 / QMB1551).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=545693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12872 / QMB1551;
RA   Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K.,
RA   Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J.,
RA   Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J.,
RA   Vary P.S.;
RT   "Genome sequences of the industrial vitamin B12-producers B.
RT   megaterium QM B1551 and DSM319 reveal new insights into the Bacillus
RT   genome evolution and pan-genome structure.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP (By similarity).
CC   -!- CATALYTIC ACTIVITY: (Z)-hexadec-11-enoyl-[acyl-carrier-protein] +
CC       malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-
CC       carrier-protein] + CO(2) + [acyl-carrier-protein].
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
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DR   EMBL; CP001983; ADE67730.1; -; Genomic_DNA.
DR   RefSeq; YP_003561164.1; NC_014019.1.
DR   EnsemblBacteria; ADE67730; ADE67730; BMQ_0696.
DR   GeneID; 8985134; -.
DR   KEGG; bmq:BMQ_0696; -.
DR   PATRIC; 35478025; VBIBacMeg35839_0688.
DR   HOGENOM; HOG000060166; -.
DR   KO; K09458; -.
DR   BioCyc; BMEG545693:GHSY-696-MONOMER; -.
DR   UniPathway; UPA00094; -.
DR   GO; GO:0033817; F:beta-ketoacyl-acyl-carrier-protein synthase II activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   PIRSF; PIRSF000447; KAS_II; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR03150; fabF; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Fatty acid biosynthesis;
KW   Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
KW   Transferase.
SQ   SEQUENCE   413 AA;  43544 MW;  1C58730E997371E5 CRC64;
     MNKKRVVVTG LGGLTPIGND VETAWKNAVA GVSGVGPLTR LDADEFPAKV AAEVKDFNVE
     DFIDRKEARK MDRFTQYAMV AALAAVKDAD LTITEEIAPN VGVWIGSGIG GMETFENQYS
     TLLEKGARRV SPFFIPMMIP DMATGQVSIA LGAKGVNSCT VTACATGTNS IGDAFKVIQR
     GDADVMVTGG TEAPITRLSI AGFCANKALS TNPDPATASR PFDKDRDGFV MGEGAGVIVL
     EELEHALARG ARIYAEIVGY GSTGDAHHIT APAPGGEGGV RAMRHAIEDA GLQPSDIDYI
     NAHGTSTGYN DKFETMAIKE VFGDHAQKVA ISSTKSMTGH LLGAAGGVEA IFSVKAIQDG
     ILPPTINYQT PDEECDLDYI PNKARKQEVK AVLSNSLGFG GHNATIIFKK YEA
//
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